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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26648
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dc.contributor.authorAlghamdi, Othman Aen
dc.contributor.authorKing, Nicolaen
dc.contributor.authorAndronicos, Nicholas Men
dc.contributor.authorJones, Graham Len
dc.contributor.authorChami, Belalen
dc.contributor.authorWitting, Paul Ken
dc.contributor.authorMoens, Pierre D Jen
dc.date.accessioned2019-04-07T23:10:43Z-
dc.date.available2019-04-07T23:10:43Z-
dc.date.issued2019-02-
dc.identifier.citationMolecular and Cellular Biochemistry, 452(1-2), p. 71-82en
dc.identifier.issn1573-4919en
dc.identifier.issn0300-8177en
dc.identifier.urihttps://hdl.handle.net/1959.11/26648-
dc.description.abstractRenal PEPT1 and PEPT2 cotransporters play an important role in the balance of circulating body oligopeptides and selected peptidomimetic drugs. We aim to comprehensively characterise age-related changes of the renal PEPT cotransporters at the gene, protein, and functional level. Brush border membrane vesicles (BBMV) and outer medulla membrane vesicles (OMMV) were isolated from the kidneys of young, middle-aged and old rats. The protein expression of PEPT1 was not only increased in BBMV from old rats, but PEPT1 also appeared in OMMV from middle-aged and old rats. SLC15A1 gene expression in the renal cortex increased in middle-aged group. PEPT2 protein expression was not only increased with ageing, but PEPT2 also was found in BBMV from middle-aged and old groups. SLC15A2 gene expression in the renal outer medulla increased in the old group. These changes in the expressions and localisations of PEPT1 and PEPT2 could explain the changes to transport activity in BBMV and OMMV. These findings provide novel insights that would be useful for maintaining protein nutrition and optimising the delivery of some peptidomimetic drugs in elderly individuals.en
dc.languageenen
dc.publisherSpringer New York LLCen
dc.relation.ispartofMolecular and Cellular Biochemistryen
dc.titleMolecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageingen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s11010-018-3413-xen
dc.identifier.pmid30019300en
local.contributor.firstnameOthman Aen
local.contributor.firstnameNicolaen
local.contributor.firstnameNicholas Men
local.contributor.firstnameGraham Len
local.contributor.firstnameBelalen
local.contributor.firstnamePaul Ken
local.contributor.firstnamePierre D Jen
local.relation.isfundedbyARCen
local.subject.for2008110101 Medical Biochemistry: Amino Acids and Metabolitesen
local.subject.for2008110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)en
local.subject.seo2008970111 Expanding Knowledge in the Medical and Health Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailnking20@une.edu.auen
local.profile.emailnandroni@une.edu.auen
local.profile.emailgjones2@une.edu.auen
local.profile.emailpmoens@une.edu.auen
local.output.categoryC1en
local.grant.numberDP160102063en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited States of Americaen
local.format.startpage71en
local.format.endpage82en
local.identifier.scopusid85049995026en
local.peerreviewedYesen
local.identifier.volume452en
local.identifier.issue1-2en
local.contributor.lastnameAlghamdien
local.contributor.lastnameKingen
local.contributor.lastnameAndronicosen
local.contributor.lastnameJonesen
local.contributor.lastnameChamien
local.contributor.lastnameWittingen
local.contributor.lastnameMoensen
dc.identifier.staffune-id:nking20en
dc.identifier.staffune-id:nandronien
dc.identifier.staffune-id:gjones2en
dc.identifier.staffune-id:pmoensen
local.profile.orcid0000-0001-5881-2296en
local.profile.orcid0000-0002-6435-1542en
local.profile.orcid0000-0003-3121-5306en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
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local.identifier.unepublicationidune:1959.11/26648en
local.date.onlineversion2018-07-17-
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleMolecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageingen
local.relation.fundingsourcenoteUniversity of New England and University of Jeddahen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.grantdescriptionARC/DP160102063en
local.search.authorAlghamdi, Othman Aen
local.search.authorKing, Nicolaen
local.search.authorAndronicos, Nicholas Men
local.search.authorJones, Graham Len
local.search.authorChami, Belalen
local.search.authorWitting, Paul Ken
local.search.authorMoens, Pierre D Jen
local.uneassociationUnknownen
local.identifier.wosid000458042200007en
local.year.available2018en
local.year.published2019en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/911d5bc8-4c63-4722-9281-e0bb564cff5cen
local.subject.for2020320803 Systems physiologyen
local.subject.seo2020200104 Prevention of human diseases and conditionsen
local.codeupdate.date2021-10-31T11:36:37.457en
local.codeupdate.epersonnandroni@une.edu.auen
local.codeupdate.finalisedtrueen
local.original.for2020320506 Medical biochemistry - proteins and peptides (incl. medical proteomics)en
local.original.for2020320501 Medical biochemistry - amino acids and metabolitesen
local.original.seo2020280112 Expanding knowledge in the health sciencesen
local.original.seo2020280103 Expanding knowledge in the biomedical and clinical scienceen
local.original.seo2020280114 Expanding knowledge in Indigenous studiesen
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