Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis

Title
Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis
Publication Date
2018
Author(s)
Le Rossignol, Scott
Ketheesan, Natkunam
( author )
OrcID: https://orcid.org/0000-0002-4870-706X
Email: nkethees@une.edu.au
UNE Id une-id:nkethees
Haleagrahara, Nagaraja
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Taylor & Francis
Place of publication
United Kingdom
DOI
10.1080/08830185.2017.1363198
UNE publication id
une:1959.11/26620
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease which is associated with significant morbidity. Redox sensitive transcription factors including NF-κB, HIF, AP-1, and Nrf2 are intimately involved in the pathogenesis of RA. The treatment of this disease is limited by the elusive nature of the pathogenesis of RA. NF-κB is crucial for the maturation of immune cells as well as production of TNFα and MMPs, which escalate RA. HIF is essential for activation of inflammatory cells, angiogenesis and pannus formation in RA. AP-1 regulates cytokine and MMP production as well as synovial hyperplasia which are key processes in RA. Nrf2 is involved with chondrogenesis, osteoblastogenesis, prostaglandin secretion and ROS production in RA. Targeting two or more of these transcription factors may result in increased efficacy than either therapy in isolation. This review will highlight the control specific mediators on these transcription factors, the subsequent effect of these transcription factors once activated, and then mesh this with the pathogenesis of RA. The elucidation of key transcription factor regulation in the pathogenesis of RA may highlight the novel therapy interventions which may prove to have a greater efficacy than those therapies currently available.
Link
Citation
International Reviews of Immunology, 37(3), p. 129-143
ISSN
1563-5244
0883-0185
1026-8006
Start page
129
End page
143

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