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Title: Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis
Contributor(s): Le Rossignol, Scott (author); Ketheesan, Natkunam  (author)orcid ; Haleagrahara, Nagaraja (author)
Publication Date: 2018
Early Online Version: 2017-09-12
DOI: 10.1080/08830185.2017.1363198
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Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease which is associated with significant morbidity. Redox sensitive transcription factors including NF-κB, HIF, AP-1, and Nrf2 are intimately involved in the pathogenesis of RA. The treatment of this disease is limited by the elusive nature of the pathogenesis of RA. NF-κB is crucial for the maturation of immune cells as well as production of TNFα and MMPs, which escalate RA. HIF is essential for activation of inflammatory cells, angiogenesis and pannus formation in RA. AP-1 regulates cytokine and MMP production as well as synovial hyperplasia which are key processes in RA. Nrf2 is involved with chondrogenesis, osteoblastogenesis, prostaglandin secretion and ROS production in RA. Targeting two or more of these transcription factors may result in increased efficacy than either therapy in isolation. This review will highlight the control specific mediators on these transcription factors, the subsequent effect of these transcription factors once activated, and then mesh this with the pathogenesis of RA. The elucidation of key transcription factor regulation in the pathogenesis of RA may highlight the novel therapy interventions which may prove to have a greater efficacy than those therapies currently available.
Publication Type: Journal Article
Source of Publication: International Reviews of Immunology, 37(3), p. 129-143
Publisher: Taylor & Francis
Place of Publication: United Kingdom
ISSN: 0883-0185
Field of Research (FOR): 119999 Medical and Health Sciences not elsewhere classified
Socio-Economic Outcome Codes: 920112 Neurodegenerative Disorders Related to Ageing
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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