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Title: Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography
Contributor(s): Pacile, Serena (author); Baran, Patrycja (author); Dullin, Christian (author); Dimmock, Matthew (author); Lockie, Darren (author); Missbach-Guntner, Jeannine (author); Quiney, Harry (author); McCormack, Mikkaela (author); Mayo, Sheridan (author); Thompson, Darren (author); Nesterets, Yakov  (author); Hall, Chris (author); Pavlov, Konstantin  (author)orcid ; Prodanovic, Zdenka (author); Tonutti, Maura (author); Accardo, Agostino (author); Fox, Jane (author); Tavakoli Taba, Seyedamir (author); Lewis, Sarah (author); Brennan, Patrick (author); Hausermann, Daniel (author); Tromba, Giuliana (author); Gureyev, Tim  (author)orcid 
Publication Date: 2018
DOI: 10.1107/S1600577518010172
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Abstract: The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.
Publication Type: Journal Article
Source of Publication: Journal of Synchrotron Radiation, 25(5), p. 1460-1466
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: United Kingdom
ISSN: 0909-0495
Field of Research (FOR): 029903 Medical Physics
020599 Optical Physics not elsewhere classified
Socio-Economic Outcome Codes: 861502 Medical Instruments
861503 Scientific Instruments
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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