Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26556
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dc.contributor.authorCharlesworth, Richard P Gen
dc.contributor.authorAgnew, Linda Len
dc.contributor.authorScott, David Ren
dc.contributor.authorAndronicos, Nicholas Men
dc.date.accessioned2019-03-28T01:47:04Z-
dc.date.available2019-03-28T01:47:04Z-
dc.date.issued2019-01-
dc.identifier.citationComputers in Biology and Medicine, v.104, p. 183-196en
dc.identifier.issn0010-4825en
dc.identifier.issn1879-0534en
dc.identifier.urihttps://hdl.handle.net/1959.11/26556-
dc.description.abstractBackground/Aim: The gold standard diagnostic for coeliac disease (CD) is subjective histological assignment of biopsies into the Marsh score categories. It is hypothesized that discrete Marsh score categories can be quantitatively resolved into a continuum using discriminant equations defined using histological and gene expression data. Therefore, the aim of this study was to use a combination of histological and gene expression data to develop equations that classify CD patient biopsies into a quantitative Marsh score continuum which could be used by clinicians to monitor CD treatment efficacy. Methods: Both empirical and simulated gene expression and histological data were used to define predictive Marsh score equations. The distances of treated sample biopsies from the Marsh score standards were determined using the Mahalanobis distance calculation. Results: Three function, high resolution discriminant equations derived from simulated data were used to accurately classify 99.6% of simulated and empirically derived biopsy data. The first function resolved active (Marsh type 3) CD from mild (Marsh type 1) CD. The second function resolved normal (no specific pathology) biopsies from mild CD. The third function resolved active Marsh score 3 into a and b subcategories. Finally, measuring the Mahalanobis distance enabled the conversion of discrete Marsh score categories into a continuum. Conclusions: This proof-of-concept study successfully demonstrated that the discrete Marsh score scale can be converted into a quantitative continuum capable of high resolution monitoring of patient treatment efficacy using equations defined by gene expression and histology data.en
dc.languageenen
dc.publisherPergamon Pressen
dc.relation.ispartofComputers in Biology and Medicineen
dc.titleEquations defined using gene expression and histological data resolve coeliac disease biopsies within the Marsh score continuumen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.compbiomed.2018.10.036en
local.contributor.firstnameRichard P Gen
local.contributor.firstnameLinda Len
local.contributor.firstnameDavid Ren
local.contributor.firstnameNicholas Men
local.subject.for2008110799 Immunology not elsewhere classifieden
local.subject.seo2008860802 Human Diagnosticsen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailrcharle3@une.edu.auen
local.profile.emaillagnew2@une.edu.auen
local.profile.emailnandroni@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited Kingdomen
local.format.startpage183en
local.format.endpage196en
local.peerreviewedYesen
local.identifier.volume104en
local.contributor.lastnameCharlesworthen
local.contributor.lastnameAgnewen
local.contributor.lastnameScotten
local.contributor.lastnameAndronicosen
dc.identifier.staffune-id:rcharle3en
dc.identifier.staffune-id:lagnew2en
dc.identifier.staffune-id:nandronien
local.profile.orcid0000-0002-2803-0995en
local.profile.orcid0000-0001-5881-2296en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/26556en
local.date.onlineversion2018-11-03-
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleEquations defined using gene expression and histological data resolve coeliac disease biopsies within the Marsh score continuumen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorCharlesworth, Richard P Gen
local.search.authorAgnew, Linda Len
local.search.authorScott, David Ren
local.search.authorAndronicos, Nicholas Men
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School of Science and Technology
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