Blood group AB is associated with severe forms of dengue virus infection

Title
Blood group AB is associated with severe forms of dengue virus infection
Publication Date
2018-03
Author(s)
Murugananthan, Kalamathy
Subramaniyam, Sivaganesh
Kumanan, Thirunavukarasu
Owens, Leigh
Ketheesan, Natkunam
( author )
OrcID: https://orcid.org/0000-0002-4870-706X
Email: nkethees@une.edu.au
UNE Id une-id:nkethees
Noordeen, Faseeha
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Springer (India) Private Ltd
Place of publication
India
DOI
10.1007/s13337-018-0426-8
UNE publication id
une:1959.11/26375
Abstract
Several viral and host factors are believed to contribute to the development of severe forms of dengue such as dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) following a dengue virus (DENV) infection. The pathogenesis of DHF/DSS is not fully understood, however, host factors like ABO blood groups have been shown to contribute to the severity of DENV infection. The present study investigated the association of blood groups with severity of DENV infection in the northern region of Sri Lanka. The blood-groups of 405 patients positive for DENV NS1 antigen and anti-DENV IgM/IgG were determined using the standard haemagglutination assay recommended by the national blood bank/s. The occurrence of severe dengue in patients with certain blood groups was significantly different (p < 0.001) to those with other blood groups. Patients with AB blood group had more than 2.5 times higher risk of developing DHF than those with other blood groups. On the other hand, patients with blood group O were significantly under represented for DHF relative to the proportion of this blood group in the general population. Thus dengue patients with blood group O appear to have a low risk of developing DHF than those with other blood groups.
Link
Citation
VirusDisease, 29(1), p. 103-105
ISSN
2347-3517
2347-3584
Pubmed ID
29607366
Start page
103
End page
105

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