Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/23304
Title: Serrulatic acid diastereomers identified from an antibacterial survey of Eremophila
Contributor(s): Lyddiard, Dane (author); Greatrex, Ben  (author)orcid 
Publication Date: 2018
Open Access: No
DOI: 10.1016/j.fitote.2017.11.013
Handle Link: https://hdl.handle.net/1959.11/23304
Abstract: In an age of growing antimicrobial resistance, new antibacterial agents are desperately needed. A rapid antibacterial and phytochemical survey was designed to screen for antibacterial leads in plants. The survey was applied to over 90 Australian native plants from the genus Eremophila, revealing Eremophila complanata and E. nivea × E. drummondii as active against Gram positive bacteria. Thin layer chromatography with bioautography, flash chromatography and nuclear magnetic resonance led to the isolation and identification of two diastereomeric serrulatic acids. A single stereoisomer of 7,8,16-trihydroxyserrulat-19-oic acid has been previously described as its methyl ester. This paper describes the NMR of both serrulatic acids epimeric at C15 and their methyl esters, and demonstrates their Gram positive antibacterial activity. It is the first time that stereoisomers of this serrulatic acid have been found together in some Eremophila species. Further characterization of E. complanata additionally found an abundance of α-selinene and β-selinene. The study validates a rapid survey approach to finding antibacterial phytochemicals.
Publication Type: Journal Article
Source of Publication: Fitoterapia, v.126, p. 29-34
Publisher: Elsevier BV
Place of Publication: The Netherlands
ISSN: 1873-6971
0367-326X
Field of Research (FOR): 030502 Natural Products Chemistry
060501 Bacteriology
030401 Biologically Active Molecules
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
920109 Infectious Diseases
970103 Expanding Knowledge in the Chemical Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Rural Medicine

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