Serrulatic acid diastereomers identified from an antibacterial survey of Eremophila

Title
Serrulatic acid diastereomers identified from an antibacterial survey of Eremophila
Publication Date
2018
Author(s)
Lyddiard, Dane
Greatrex, Ben
( author )
OrcID: https://orcid.org/0000-0002-0356-4966
Email: bgreatre@une.edu.au
UNE Id une-id:bgreatre
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Elsevier BV
Place of publication
Netherlands
DOI
10.1016/j.fitote.2017.11.013
UNE publication id
une:23486
Abstract
In an age of growing antimicrobial resistance, new antibacterial agents are desperately needed. A rapid antibacterial and phytochemical survey was designed to screen for antibacterial leads in plants. The survey was applied to over 90 Australian native plants from the genus Eremophila, revealing Eremophila complanata and E. nivea × E. drummondii as active against Gram positive bacteria. Thin layer chromatography with bioautography, flash chromatography and nuclear magnetic resonance led to the isolation and identification of two diastereomeric serrulatic acids. A single stereoisomer of 7,8,16-trihydroxyserrulat-19-oic acid has been previously described as its methyl ester. This paper describes the NMR of both serrulatic acids epimeric at C15 and their methyl esters, and demonstrates their Gram positive antibacterial activity. It is the first time that stereoisomers of this serrulatic acid have been found together in some Eremophila species. Further characterization of E. complanata additionally found an abundance of α-selinene and β-selinene. The study validates a rapid survey approach to finding antibacterial phytochemicals.
Link
Citation
Fitoterapia, v.126, p. 29-34
ISSN
1971-551X
0367-326X
Start page
29
End page
34

Files:

NameSizeformatDescriptionLink
administrative/MODS.xml 4.651 KB MODS.xml View document
closedpublished/SOURCE01.pdf 233.27 KB application/pdf publisher version (hidden) View document
closed/SOURCE02.pdf 1411.368 KB application/pdf post-peer review version (hidden) View document
closed/SOURCE03.pdf 3069.398 KB application/pdf administrative (hidden) View document
closed/SOURCE04.pdf 144.886 KB application/pdf administrative (hidden) View document
open/SerrulaticGreatrex2018JournalArticlePostPeerReview.pdf 1473.407 KB application/pdf Open access version View document