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https://hdl.handle.net/1959.11/23293| Title: | Zeitabhängige genetische Effekte während der Laktation in Deutschen Holstein Rindern | English Title: | Time-dependent genetic effects during a lactation of German Holstein cows | Contributor(s): | Strucken, Eva (author) ; Brockmann, Gudrun (author) |
Publication Date: | 2012 | Handle Link: | https://hdl.handle.net/1959.11/23293 | Publication Type: | Conference Publication | Conference Details: | Symposium "Milchrind", Berlin, Germany, 29th November 2012 | Source of Publication: | Symposium "Milchrind" Programm, p. 5-5 | Publisher: | Humboldt-Universitat zu Berlin | Place of Publication: | Berlin, Germany | Fields of Research (FoR) 2008: | 070201 Animal Breeding 060408 Genomics |
Fields of Research (FoR) 2020: | 300305 Animal reproduction and breeding 310509 Genomics |
Socio-Economic Objective (SEO) 2008: | 830302 Dairy Cattle 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences 830507 Unprocessed or Minimally Processed Milk |
Socio-Economic Objective (SEO) 2020: | 100402 Dairy cattle 280101 Expanding knowledge in the agricultural, food and veterinary sciences 100606 Unprocessed or minimally processed milk |
HERDC Category Description: | E3 Extract of Scholarly Conference Publication | English Abstract: | The variability of milk production during a lactation can be seen directly in the daily yields. However, because high producing dairy cows develop an energy deficit especially in early lactation, which can have far-reaching consequences, it is sensible to breed for a low production yield in the first lactation weeks. Simultaneously, a good persistency can improve the overall yield to satisfy the farmers' and consumers' demands. From mammogenesis to actual milk synthesis in the mammary glands, many time points and mechanisms take part in the physiological time-dependent expression of milk. The largest complexes involved in milk production cover hormone and growth factors, feed intake and digestion, cell activity, nutrient transportation and synthesis. Despite these various starting points that impact upon milk production, only few genes have been identified. This could be due to many association studies using averaged yields and therefore not being able to detect genes that are only relevant during a specific time-point. We developed an approach to carry out association studies in regards to specific lactation periods. These periods were defined as the yield increase before the maximum, the persistency, and the overall level of production. With this approach we were able to show that the DGAT1 gene expresses its known genotype effects only after lactation day 40, and that several groups of markers are significant for the three different production periods. Further, gene enrichment studies showed that genes with different functions were accumulated around significant markers. Such gene groups were involved in the regulation of cell growth, gene expression and transcript regulation, the energy supply of cells, fat and protein synthesis, and immune response, which were specific for individual periods. Time-dependent association studies can provide new insights into the regulation of milk production. We could asses the processes of milk production that will be altered when breeding for significant markers. Genomic selection could incorporate time-dependencies and thus selectively change the production curve to improve the overall yield as well as animal health and fertility. |
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| Appears in Collections: | Conference Publication School of Environmental and Rural Science |
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