Anti-troponin antibodies following myocardial infarction

Title
Anti-troponin antibodies following myocardial infarction
Publication Date
2017
Author(s)
O'Donohoe, Tom J
Ketheesan, Natkunam
( author )
OrcID: https://orcid.org/0000-0002-4870-706X
Email: nkethees@une.edu.au
UNE Id une-id:nkethees
Schrale, Ryan G
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Elsevier BV
Place of publication
Netherlands
DOI
10.1016/j.jjcc.2016.07.018
UNE publication id
une:23399
Abstract
Recent improvements in medical and surgical coronary revascularization techniques have significantly improved outcomes for patients with acute myocardial infarction (MI). However, large infarctions are often followed by a poorly understood process of pathological ventricular remodelling, which fails to return the heart to its premorbid state. Although it remains incompletely understood, there is increasing interest in the role of the immune system in this process. One hypothesis is that released cardiac proteins become the focus of an immune response that results in the formation of functionally significant autoantibodies. This review summarizes the current literature, both human and animal, relating to the formation and clinical relevance of anti-troponin antibodies (ATAs) in patients with MI.
Link
Citation
Journal of Cardiology, 69(1), p. 38-45
ISSN
1876-4738
0914-5087
Start page
38
End page
45

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