Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/23192
Title: | Clinical outcomes to exercise training in type 1 diabetes: A systematic review and meta-analysis | Contributor(s): | Ostman, Cecilia (author); Jewiss, Daniel (author); King, N (author); Smart, Neil (author) | Publication Date: | 2018 | Open Access: | Yes | DOI: | 10.1016/j.diabres.2017.11.036 | Handle Link: | https://hdl.handle.net/1959.11/23192 | Abstract: | Aims To establish the relationship between exercise training and clinical outcomes in people with type I diabetes. Methods Studies were identified through a MEDLINE search strategy, Cochrane Controlled Trials Registry, CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of key concepts related to trials of exercise training in people with type 1 diabetes; glycaemic control. Searches were limited to prospective randomized or controlled trials of exercise training in humans with type 1 diabetes lasting 12 weeks or more. Results In exercised adults there were significant improvements in body mass Mean Difference (MD): -2.20 kg, 95% Confidence Interval (CI) -3.79-0.61, p=.007; body mass index (BMI) MD: -0.39 kg/m2, 95% CI -0.75-0.02, p=.04; Peak VO₂ MD: 4.08 ml/kg/min, 95% CI -2.18-5.98, p<.0001; and, low-density lipoprotein cholesterol (LDL) MD: -0.21 mmol/L, 95% CI -0.33-0.08, p=.002. In exercised children there were significant improvements in insulin dose MD: -0.23 IU/kg, 95% CI -0.37-0.09, p=.002; waist circumference MD: -5.40 cm, 95% CI -8.45 to -2.35, p=.0005; LDL MD: -0.31 mmol/L, 95% CI -0.55 to -0.06, p=.02; and, triglycerides MD: -0.21 mmol/L, 95% CI -0.42 to -0.01, p=.04. There were no significant changes in glycosylated haemoglobin (HbA1C%), fasting blood glucose, resting heart rate, resting systolic blood pressure or high density lipoproteins in either group. Conclusions Exercise training improves some markers of type 1 diabetes severity; particularly body mass, BMI, Peak VO₂ and LDL in adults and insulin dose, waist circumference, LDL and triglycerides in children. | Publication Type: | Journal Article | Source of Publication: | Diabetes Research and Clinical Practice, v.139, p. 380-391 | Publisher: | Elsevier Ireland Ltd | Place of Publication: | Ireland | ISSN: | 1872-8227 0168-8227 |
Fields of Research (FoR) 2008: | 110602 Exercise Physiology 110201 Cardiology (incl. Cardiovascular Diseases) 110306 Endocrinology |
Fields of Research (FoR) 2020: | 320101 Cardiology (incl. cardiovascular diseases) 320208 Endocrinology |
Socio-Economic Objective (SEO) 2008: | 920201 Allied Health Therapies (excl. Mental Health Services) 920103 Cardiovascular System and Diseases 920106 Endocrine Organs and Diseases (excl. Diabetes) |
Socio-Economic Objective (SEO) 2020: | 200301 Allied health therapies (excl. mental health services) | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Rural Medicine School of Science and Technology |
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File | Description | Size | Format | |
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open/ClinicalSmart2018JournalArticlePostPeerReview.pdf | Open access version | 1.16 MB | Adobe PDF Download Adobe | View/Open |
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