Therapeutic effect of quercetin in collagen-induced arthritis

Title
Therapeutic effect of quercetin in collagen-induced arthritis
Publication Date
2017
Author(s)
Haleagrahara, Nagaraja
Miranda-Hernandez, Socorro
Alim, Md Abdul
Hayes, Linda
Bird, Guy
Ketheesan, Natkunam
( author )
OrcID: https://orcid.org/0000-0002-4870-706X
Email: nkethees@une.edu.au
UNE Id une-id:nkethees
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Elsevier Masson
Place of publication
France
DOI
10.1016/j.biopha.2017.03.026
UNE publication id
une:23372
Abstract
Quercetin, a bioactive flavonoid with anti-inflammatory, immunosuppressive,and protective properties, is a potential agent for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is the most commonly used animal model for studying the pathogenesis of RA. This study analysed the therapeutic role of quercetin in collagen-induced arthritis in C57BL/6 mice. The animals were allocated into five groups that were subjected to the following treatments: negative (untreated) control, positive control (arthritis-induced), arthritis+methotrexate, arthritis+quercetin, and arthritis+methotrexate+quercetin. Assessments of weight, oedema, joint damage, and cytokine production were used to determine the therapeutic effect of quercetin. This study demonstrated for the first time the anti-inflammatory and protective effects of quercetin in vivo in CIA. The results also showed that the concurrent administration of quercetin and methotrexate did not offer greater protection than the administration of a single agent. The use of quercetin as a monotherapeutic agent resulted in the lowest degree of joint inflammation and the highest protection.The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-α, IL-1 β, IL-17, and MCP-1. In conclusion, this study determined that quercetin, which was non-toxic, produced better results than methotrexate for the protection of joints from arthritic inflammation in mice. Quercetin may be an alternative treatment for RA because it modulates the main pathogenic pathways of RA.
Link
Citation
Biomedicine & Pharmacotherapy, v.90, p. 38-46
ISSN
1950-6007
0753-3322
Start page
38
End page
46

Files:

NameSizeformatDescriptionLink