The therapeutic potential of plant flavonoids on rheumatoid arthritis

Title
The therapeutic potential of plant flavonoids on rheumatoid arthritis
Publication Date
2017
Author(s)
Hughes, Samuel D
Ketheesan, Natkunam
( author )
OrcID: https://orcid.org/0000-0002-4870-706X
Email: nkethees@une.edu.au
UNE Id une-id:nkethees
Haleagrahara, Nagaraja
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Taylor & Francis Inc
Place of publication
United States of America
DOI
10.1080/10408398.2016.1246413
UNE publication id
une:23371
Abstract
Rheumatoid arthritis (RA) is an autoimmune condition that mainly affects peripheral joints. Although immunosuppressive drugs and non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat this condition, these drugs have severe side effects. Flavonoids are the most abundant phenolic compounds which exhibit anti-oxidant, anti-inflammatory and immunomodulatory properties. Many bioactive flavonoids have powerful anti-inflammatory effects. However, a very few have reached clinical use. Dietary flavonoids have been reported to control joint inflammation and alleviate arthritis symptoms in both human RA and animal models of arthritis. There is little scientific evidence about their mechanism of actions in RA. We review the therapeutic effects of different groups of flavonoids belonging to the most common and abundant groups on RA. In particular, the probable mechanisms of major flavonoids on cells and chemical messengers involved in the inflammatory signaling components of RA are discussed in detail.
Link
Citation
Critical Reviews in Food Science and Nutrition, 57(17), p. 3601-3613
ISSN
1549-7852
1040-8398
Start page
3601
End page
3613

Files:

NameSizeformatDescriptionLink