Kitchen, Marcus J; Buckley, Genevieve A; Gureyev, Timur; Wallace, Megan J; Andres-Thio, Nico; Uesugi, Kentaro; Yagi, Naoto; Hooper, Stuart B

Author(s)

Kitchen, Marcus J

Buckley, Genevieve A

Gureyev, Timur

Wallace, Megan J

Andres-Thio, Nico

Uesugi, Kentaro

Yagi, Naoto

Hooper, Stuart B

Publication Date

2017

Abstract

Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order of magnitude or more compared to conventional radiographs. Combining phase retrieval with computed tomography (CT) can increase the signal-to-noise ratio (SNR) by up to two orders of magnitude over conventional CT at the same radiation dose, without loss of image quality. Our experiments reveal that as the radiation dose decreases, the relative improvement in SNR increases. We show that this enhancement can be traded for a reduction in dose greater than the square of the gain in SNR. Upon reducing the dose 300 fold, the phase-retrieved SNR was still up to 9.6 ± 0.2 times larger than the absorption contrast data with spatial resolution in the tens of microns. We show that this theoretically reveals the potential for dose reduction factors in the tens of thousands without loss in image quality, which would have a profound impact on medical and industrial imaging applications.

Citation

Scientific Reports, v.7, p. 1-9

ISSN

2045-2322

Link

https://hdl.handle.net/1959.11/23017

Publisher

Nature Publishing Group

Title

CT dose reduction factors in the thousands using X-ray phase contrast

Type of document

Journal Article

Entity Type

Publication

Author(s)	Kitchen, Marcus J Buckley, Genevieve A Gureyev, Timur Wallace, Megan J Andres-Thio, Nico Uesugi, Kentaro Yagi, Naoto Hooper, Stuart B
Publication Date	2017
Abstract	Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order of magnitude or more compared to conventional radiographs. Combining phase retrieval with computed tomography (CT) can increase the signal-to-noise ratio (SNR) by up to two orders of magnitude over conventional CT at the same radiation dose, without loss of image quality. Our experiments reveal that as the radiation dose decreases, the relative improvement in SNR increases. We show that this enhancement can be traded for a reduction in dose greater than the square of the gain in SNR. Upon reducing the dose 300 fold, the phase-retrieved SNR was still up to 9.6 ± 0.2 times larger than the absorption contrast data with spatial resolution in the tens of microns. We show that this theoretically reveals the potential for dose reduction factors in the tens of thousands without loss in image quality, which would have a profound impact on medical and industrial imaging applications.
Citation	Scientific Reports, v.7, p. 1-9
ISSN	2045-2322
Link	https://hdl.handle.net/1959.11/23017
Publisher	Nature Publishing Group
Title	CT dose reduction factors in the thousands using X-ray phase contrast
Type of document	Journal Article
Entity Type	Publication

CT dose reduction factors in the thousands using X-ray phase contrast

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