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https://hdl.handle.net/1959.11/22985
Title: | Does psychological resilience buffer against the link between the 5-HTTLPR polymorphism and depression following stress? | Contributor(s): | Sharpley, Christopher (author) ; Christie, David (author); Bitsika, Vicki (author) ; Agnew, Linda (author) ; Andronicos, Nicholas (author) ; McMillan, Mary (author) | Publication Date: | 2017 | DOI: | 10.1016/j.physbeh.2017.07.029 | Handle Link: | https://hdl.handle.net/1959.11/22985 | Abstract: | The comparative strength of the 5-HTTLPR polymorphism as a 'predictor' of depression after major stress, versus the 'protective' effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression. These data suggest that the carriage of the short form of the 5-HTTLPR may negate the protective effect of PR against depression in these men, or that PR may nullify the depression vulnerability of this form of the 5-HTTLPR. These findings may explain some of the 'null' findings regarding the link between the 5-HTTLPR and depression in the wider literature by arguing for an interaction between these two factors in the association between major stress and depression. | Publication Type: | Journal Article | Source of Publication: | Physiology & Behavior, v.180, p. 53-59 | Publisher: | Elsevier Inc | Place of Publication: | United States of America | ISSN: | 1873-507X 0031-9384 |
Fields of Research (FoR) 2008: | 110903 Central Nervous System | Fields of Research (FoR) 2020: | 320903 Central nervous system | Socio-Economic Objective (SEO) 2008: | 920111 Nervous System and Disorders | Socio-Economic Objective (SEO) 2020: | 200409 Mental health | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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