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|Title:||Does psychological resilience buffer against the link between the 5-HTTLPR polymorphism and depression following stress?||Contributor(s):||Sharpley, Christopher (author) ; Christie, David (author); Bitsika, Vicki (author); Agnew, Linda (author) ; Andronicos, Nicholas (author) ; McMillan, Mary (author)||Publication Date:||2017||DOI:||10.1016/j.physbeh.2017.07.029||Handle Link:||https://hdl.handle.net/1959.11/22985||Abstract:||The comparative strength of the 5-HTTLPR polymorphism as a 'predictor' of depression after major stress, versus the 'protective' effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression. These data suggest that the carriage of the short form of the 5-HTTLPR may negate the protective effect of PR against depression in these men, or that PR may nullify the depression vulnerability of this form of the 5-HTTLPR. These findings may explain some of the 'null' findings regarding the link between the 5-HTTLPR and depression in the wider literature by arguing for an interaction between these two factors in the association between major stress and depression.||Publication Type:||Journal Article||Source of Publication:||Phsyiology and Behavior, v.180, p. 53-59||Publisher:||Elsevier Ltd||Place of Publication:||United States of America||ISSN:||0031-9384
|Field of Research (FOR):||110903 Central Nervous System||Socio-Economic Outcome Codes:||920111 Nervous System and Disorders||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 6
|Appears in Collections:||Journal Article|
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