Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22947
Title: Genome-wide associations for investigating time-dependent genetic effects for milk production traits in dairy cattle
Contributor(s): Strucken, Eva  (author)orcid ; Bortfeldt, R H (author); de Koning, D J (author); Brockmann, G A (author)
Publication Date: 2012
DOI: 10.1111/j.1365-2052.2011.02278.x
Handle Link: https://hdl.handle.net/1959.11/22947
Abstract: Phenotypic variation in milk production traits has been described over the course of a lactation as well as between different parities. The objective of this study was to investigate whether variation in production is affected by different loci across lactations. A genome-wide association study (GWAS) using a 50-k SNP chip was conducted in 152 divergent German Holstein Friesian cows to test for association with milk production traits over different lactations. The first four lactations were analysed regarding milk yield, fat, protein, lactose, milk urea nitrogen yield and content as well as somatic cell score. Two approaches were used: (i) Wilmink curve parameters were used to assess the genetic effects over the course of a lactation and (ii) test-day yield deviations (YD) were used as a normative approach for a GWAS. The significant effects were largest for markers affecting curve parameters for which there was a statistical power <0.8 of detection even in this small design. While significant markers for YDs were detected in this study, the power to detect effects of a similar magnitude was only 0.11, suggesting that many loci may have been missed with this approach in the present design. Furthermore, all significant effects were specific for a single lactation, leading to the conclusion that the variance explained by a certain locus changes from lactation to lactation. We confirm the common evidence that most production traits vary in the degree of persistency after the peak as a result of genetic influence.
Publication Type: Journal Article
Source of Publication: Animal Genetics, 43(4), p. 375-382
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: United Kingdom
ISSN: 1365-2052
0268-9146
Fields of Research (FoR) 2008: 070201 Animal Breeding
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
Socio-Economic Objective (SEO) 2008: 830302 Dairy Cattle
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
830507 Unprocessed or Minimally Processed Milk
Socio-Economic Objective (SEO) 2020: 100402 Dairy cattle
280101 Expanding knowledge in the agricultural, food and veterinary sciences
100606 Unprocessed or minimally processed milk
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

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