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Title: Variations in the Relative mRNA Levels of Actins and Myosin Heavy Chains do not Produce Corresponding Differences in their Proteins in the Adult Human Heart
Contributor(s): Coumans-Moens, Joelle (author)orcid ; Yeoh, Thomas (author); Seeto, Reginald K (author); Keogh, Anne (author); Brennan, Karen (author); Gunning, Peter (author); Hardeman, Edna (author); dos Remedios, Cristobal G (author)
Publication Date: 1997
DOI: 10.1006/jmcc.1996.0317
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Abstract: This paper examines the quantitative relationship between the expression of myosin heavy chain (MHC) and actin at both the levels of their mRNAs and their proteins. Explanted human left ventricle tissues were obtained from non-diseased (ND) individuals and from dilated cardiomyopathy (DCM) patients with terminally failing hearts who underwent heart transplantation. We found: (1) there are substantial differences in the stoichiometry of sarcomeric MHC and actin transcripts in hearts of DCM patients as well as in ND individuals; (2) there are substantial differences between levels of total sarcomeric actin transcripts from different individual patients; (3) by and large variations in transcript levels between samples from the same heart are much less than between samples from different hearts; and (4) the ratio of MHC to sarcomeric actin proteins expressed by different ND and DCM hearts remains essentiallly constant. We conclude that the human ventricle can accomodate a substantial imbalance between sarcomeric MHC and actin mRNA levels while maintaining a constant ratio of their corresponding proteins.
Publication Type: Journal Article
Source of Publication: Journal of Molecular and Cellular Cardiology, 29(3), p. 895-905
Publisher: Academic Press
Place of Publication: United Kingdom
ISSN: 1095-8584
Field of Research (FOR): 060101 Analytical Biochemistry
060199 Biochemistry and Cell Biology not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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