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Title: Neurobiological and psychological evidence of chronic stress in prostate cancer patients
Contributor(s): Sharpley, Christopher  (author)orcid ; Christie, D R H (author); Bitsika, V (author); Agnew, Linda  (author)orcid ; Andronicos, N M (author); McMillan, M E (author); Richards, T M (author)
Publication Date: 2017
DOI: 10.1111/ecc.12671
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Abstract: To measure the prevalence and severity of Generalised Anxiety Disorder (GAD), hypo-and hypercortisolaemia, and their association in a sample of prostate cancer (PCa) patients, 97 Australian PCa patients completed a background questionnaire and the GAD-7, and provided a sample of saliva collected 30-45 min after waking. The mean GAD7 score was 9.67 (SD = 3.09), and prevalence rates for current anxiety were higher than those reported for non-PCa males of a similar age. Mean salivary cortisol concentrations (30.78 nmol/L, SD = 13.97 nmol/L) were also higher than for age-comparative non-PCa men. There was a significant inverse correlation between GAD and cortisol (r = -. 209, p < .05), and four subgroups of GAD-cortisol patients were able to be identified, with evidence of both hyper-and hypocortisolaemia. These findings provide initial neurobiological evidence of the chronic and profound nature of stress experienced by PCa patients, and also suggest a possible measure that might be used to identify most at-risk PCa patients.
Publication Type: Journal Article
Source of Publication: European Journal of Cancer Care, 26(6), p. 1-7
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: United Kingdom
ISSN: 1365-2354
Field of Research (FOR): 110903 Central Nervous System
Socio-Economic Outcome Codes: 920111 Nervous System and Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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