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Title: The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients
Contributor(s): Sharpley, Christopher  (author)orcid ; Christie, David R H  (author); Bitsika, Vicki  (author)orcid ; Agnew, Linda  (author)orcid ; Andronicos, Nicholas  (author)orcid ; McMillan, Mary  (author)orcid ; Richards, Timothy M (author)
Publication Date: 2017
DOI: 10.1002/pon.4327
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Abstract: Cortisol is a neurohormone released after a cascade response to stressors that begins in the hypothalamus, moves to the pituitary gland, and then to the adrenals, which secrete cortisol into the bloodstream as the final stage in this cascade. Cortisol affects many physiological functions, including vital anti‐inflammatory and immunosuppressive actions, as well as metabolism and homeostasis. Consequently, a basal concentration of cortisol is required at all times but may become immediately elevated in response to physical or mental stressors, usually returning to basal levels later. Underneath this immediate response to stressors, cortisol displays a diurnal variation so that concentrations are at their apex about 45 min after waking in the morning and decrease to their nadir in the early evening, a process referred to as the diurnal fluctuation in cortisol. However, this variation may become dysregulated by chronic stress and instead become consistently elevated, resulting in hypercortisolemia, which is characterized by an ongoing elevated concentration of cortisol in the bloodstream that is associated with pain, fatigue, increased risk of heart disease, and the symptoms of anxiety, muscle wastage, and hyperglycemia.
Publication Type: Journal Article
Source of Publication: Psycho-Oncology, 26(9), p. 1400-1402
Publisher: John Wiley & Sons Ltd
Place of Publication: United Kingdom
ISSN: 1099-1611
Fields of Research (FoR) 2008: 110903 Central Nervous System
Fields of Research (FoR) 2020: 320903 Central nervous system
Socio-Economic Objective (SEO) 2008: 920111 Nervous System and Disorders
Socio-Economic Objective (SEO) 2020: 200409 Mental health
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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