The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients

Title
The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients
Publication Date
2017
Author(s)
Sharpley, Christopher
( author )
OrcID: https://orcid.org/0000-0001-7922-4848
Email: csharpl3@une.edu.au
UNE Id une-id:csharpl3
Christie, David R H
Bitsika, Vicki
( author )
OrcID: https://orcid.org/0000-0003-2518-6684
Email: vbitsik2@une.edu.au
UNE Id une-id:vbitsik2
Agnew, Linda
( author )
OrcID: https://orcid.org/0000-0002-2803-0995
Email: lagnew2@une.edu.au
UNE Id une-id:lagnew2
Andronicos, Nicholas
( author )
OrcID: https://orcid.org/0000-0001-5881-2296
Email: nandroni@une.edu.au
UNE Id une-id:nandroni
McMillan, Mary
( author )
OrcID: https://orcid.org/0000-0002-2336-3985
Email: mrookle2@une.edu.au
UNE Id une-id:mrookle2
Richards, Timothy M
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
John Wiley & Sons Ltd
Place of publication
United Kingdom
DOI
10.1002/pon.4327
UNE publication id
une:23048
Abstract
Cortisol is a neurohormone released after a cascade response to stressors that begins in the hypothalamus, moves to the pituitary gland, and then to the adrenals, which secrete cortisol into the bloodstream as the final stage in this cascade. Cortisol affects many physiological functions, including vital anti‐inflammatory and immunosuppressive actions, as well as metabolism and homeostasis. Consequently, a basal concentration of cortisol is required at all times but may become immediately elevated in response to physical or mental stressors, usually returning to basal levels later. Underneath this immediate response to stressors, cortisol displays a diurnal variation so that concentrations are at their apex about 45 min after waking in the morning and decrease to their nadir in the early evening, a process referred to as the diurnal fluctuation in cortisol. However, this variation may become dysregulated by chronic stress and instead become consistently elevated, resulting in hypercortisolemia, which is characterized by an ongoing elevated concentration of cortisol in the bloodstream that is associated with pain, fatigue, increased risk of heart disease, and the symptoms of anxiety, muscle wastage, and hyperglycemia.
Link
Citation
Psycho-Oncology, 26(9), p. 1400-1402
ISSN
1099-1611
1057-9249
Start page
1400
End page
1402

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