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|Title:||Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model||Contributor(s):||Xue, Guang-Da (author); Wu, Shubiao (author) ; Choct, Mingan (author) ; Swick, Robert A (author)||Publication Date:||2017||Open Access:||Yes||DOI:||10.1016/j.aninu.2017.08.002||Handle Link:||https://hdl.handle.net/1959.11/22830||Abstract:||Subclinical necrotic enteritis (NE) causes devastating economic losses in the broiler chicken industry, especially in birds raised free of in-feed antibiotics. Prebiotics are potential alternatives to in-feed antibiotics. Yeast cell wall extract (YCW) derived from Saccharomyces cerevisiae is a prebiotic with known immune modulating effects. This study examined the effects of YCW and antibiotics (AB) during subclinical NE on broiler growth performance, intestinal lesions, humoral immune response and gut microflora metabolites. The study employed a 2×3 factorial arrangement of treatments. Factors were: NE challenge (yes or no) and feed additive (control, AB, or YCW). Each treatment was replicated in 8 floor pens with 15 birds per pen. Challenged birds had higher feed conversion ratio (FCR) than unchallenged birds on d 35 (P < 0.05). Dietary inclusion of AB decreased FCR regardless of challenge (P < 0.05) on d 24 and 35. Inclusion of YCW reduced serum interleukin-1 (IL-1) concentration in NE challenged birds (P < 0.01) and increased immunoglobulin (Ig) G (P < 0.05) and Ig M (P < 0.05) levels compared to other dietary treatments regardless of challenge. Yeast cell wall extract increased formic acid concentration in cecal contents during challenge and increased butyric acid concentration in unchallenged birds on d 16. This study indicates YCW suppressed inflammatory response, promoted generation of immunoglobulin and increased short chain fatty acid production suggesting potential benefits to bird health.||Publication Type:||Journal Article||Source of Publication:||Animal Nutrition, 3(4), p. 399-405||Publisher:||Zhongguo Xumu Shouyi Xuehui [Chinese Association of Animal Science and Veterinary Medicine]||Place of Publication:||China||ISSN:||2405-6545||Field of Research (FOR):||070204 Animal Nutrition||Socio-Economic Outcome Codes:||839999 Animal Production and Animal Primary Products not elsewhere classified||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 9
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School of Environmental and Rural Science
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