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Title: Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model
Contributor(s): Xue, Guang-Da (author); Wu, Shubiao  (author)orcid ; Choct, Mingan  (author)orcid ; Swick, Robert A  (author)orcid 
Publication Date: 2017
Open Access: Yes
DOI: 10.1016/j.aninu.2017.08.002Open Access Link
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Abstract: Subclinical necrotic enteritis (NE) causes devastating economic losses in the broiler chicken industry, especially in birds raised free of in-feed antibiotics. Prebiotics are potential alternatives to in-feed antibiotics. Yeast cell wall extract (YCW) derived from Saccharomyces cerevisiae is a prebiotic with known immune modulating effects. This study examined the effects of YCW and antibiotics (AB) during subclinical NE on broiler growth performance, intestinal lesions, humoral immune response and gut microflora metabolites. The study employed a 2×3 factorial arrangement of treatments. Factors were: NE challenge (yes or no) and feed additive (control, AB, or YCW). Each treatment was replicated in 8 floor pens with 15 birds per pen. Challenged birds had higher feed conversion ratio (FCR) than unchallenged birds on d 35 (P < 0.05). Dietary inclusion of AB decreased FCR regardless of challenge (P < 0.05) on d 24 and 35. Inclusion of YCW reduced serum interleukin-1 (IL-1) concentration in NE challenged birds (P < 0.01) and increased immunoglobulin (Ig) G (P < 0.05) and Ig M (P < 0.05) levels compared to other dietary treatments regardless of challenge. Yeast cell wall extract increased formic acid concentration in cecal contents during challenge and increased butyric acid concentration in unchallenged birds on d 16. This study indicates YCW suppressed inflammatory response, promoted generation of immunoglobulin and increased short chain fatty acid production suggesting potential benefits to bird health.
Publication Type: Journal Article
Source of Publication: Animal Nutrition, 3(4), p. 399-405
Publisher: Zhongguo Xumu Shouyi Xuehui, Chinese Association of Animal Science and Veterinary Medicine
Place of Publication: China
ISSN: 2405-6383
Fields of Research (FoR) 2008: 070204 Animal Nutrition
Fields of Research (FoR) 2020: 300303 Animal nutrition
Socio-Economic Objective (SEO) 2008: 839999 Animal Production and Animal Primary Products not elsewhere classified
Socio-Economic Objective (SEO) 2020: 109999 Other animal production and animal primary products not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

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