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Title: Increased Neurotropic Threat from 'Burkholderia pseudomallei' Strains with a 'B mallei'-like Variation in the 'bimA' Motility Gene, Australia
Contributor(s): Morris, Jodie L (author); Fane, Anne (author); Sarovich, Derek S (author); Price, Erin P (author); Rush, Catherine M (author); Govan, Brenda L (author); Parker, Elizabeth (author); Mayo, Mark (author); Currie, Bart J (author); Ketheesan, Natkunam  (author)orcid 
Publication Date: 2017
Open Access: Yes
DOI: 10.3201/eid2305.151417Open Access Link
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Abstract: Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
Publication Type: Journal Article
Source of Publication: Emerging Infectious Diseases, 23(5), p. 740-749
Publisher: Centers for Disease Control and Prevention (CDC)
Place of Publication: United States of America
ISSN: 1080-6040
Field of Research (FOR): 119999 Medical and Health Sciences not elsewhere classified
110801 Medical Bacteriology
Socio-Economic Outcome Codes: 920109 Infectious Diseases
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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