Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22509
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dc.contributor.authorLee, Sang Hongen
dc.contributor.authorWeerasinghe, W M Shalanee Pen
dc.contributor.authorVan Der Werf, Julius Hen
dc.date.accessioned2018-02-13T14:30:00Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports, v.7, p. 1-12en
dc.identifier.issn2045-2322en
dc.identifier.urihttps://hdl.handle.net/1959.11/22509-
dc.description.abstractWe estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intelligence (p-value = 3.9E-05) when comparing the group of individuals who were breastfed with maternal smoking with those not breastfed without maternal smoking. Genome-wide significant SNPs were different between different environmental groups. Genomic prediction accuracies were significantly higher when using the target and discovery sample from the same environmental group than when using those from the different environmental groups. This finding demonstrates G × E has important implications for future studies on the genetic architecture, genome-wide association studies and genomic predictions.en
dc.languageenen
dc.publisherNature Publishing Groupen
dc.relation.ispartofScientific Reportsen
dc.titleGenotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birthen
dc.typeJournal Articleen
dc.identifier.doi10.1038/s41598-017-06214-yen
dcterms.accessRightsGolden
dc.subject.keywordsEpidemiologyen
dc.subject.keywordsQuantitative Genetics (incl. Disease and Trait Mapping Genetics)en
local.contributor.firstnameSang Hongen
local.contributor.firstnameW M Shalanee Pen
local.contributor.firstnameJulius Hen
local.subject.for2008060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)en
local.subject.for2008111706 Epidemiologyen
local.subject.seo2008920401 Behaviour and Healthen
local.subject.seo2008920412 Preventive Medicineen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailslee38@une.edu.auen
local.profile.emailjvanderw@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20170807-095400en
local.publisher.placeUnited Kingdomen
local.identifier.runningnumber6087en
local.format.startpage1en
local.format.endpage12en
local.identifier.scopusid85025466154en
local.peerreviewedYesen
local.identifier.volume7en
local.access.fulltextYesen
local.contributor.lastnameLeeen
local.contributor.lastnameWeerasingheen
local.contributor.lastnameVan Der Werfen
dc.identifier.staffune-id:slee38en
dc.identifier.staffune-id:jvanderwen
local.profile.orcid0000-0003-2512-1696en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:22697en
local.identifier.handlehttps://hdl.handle.net/1959.11/22509en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleGenotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birthen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.grantdescriptionARC/DP160102126en
local.relation.grantdescriptionNHMRC/1080157en
local.search.authorLee, Sang Hongen
local.search.authorWeerasinghe, W M Shalanee Pen
local.search.authorVan Der Werf, Julius Hen
local.uneassociationUnknownen
local.identifier.wosid000405907800141en
local.year.published2017en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/9987206e-17cc-4a15-999e-808faa3d1ac1en
local.subject.for2020310506 Gene mappingen
local.subject.seo2020200401 Behaviour and healthen
local.subject.seo2020200412 Preventive medicineen
dc.notification.token1b32f10e-7456-4b18-bafa-8da36ef320ceen
Appears in Collections:Journal Article
School of Environmental and Rural Science
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