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Title: Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
Contributor(s): Lee, Sang Hong  (author); Weerasinghe, W M Shalanee P (author); Van Der Werf, Julius H  (author)orcid 
Publication Date: 2017
Open Access: Yes
DOI: 10.1038/s41598-017-06214-yOpen Access Link
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Abstract: We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intelligence (p-value = 3.9E-05) when comparing the group of individuals who were breastfed with maternal smoking with those not breastfed without maternal smoking. Genome-wide significant SNPs were different between different environmental groups. Genomic prediction accuracies were significantly higher when using the target and discovery sample from the same environmental group than when using those from the different environmental groups. This finding demonstrates G × E has important implications for future studies on the genetic architecture, genome-wide association studies and genomic predictions.
Publication Type: Journal Article
Grant Details: ARC/DP160102126
Source of Publication: Scientific Reports, v.7, p. 1-12
Publisher: Nature Publishing Group
Place of Publication: United Kingdom
ISSN: 2045-2322
Fields of Research (FoR) 2008: 060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
111706 Epidemiology
Fields of Research (FoR) 2020: 310506 Gene mapping
Socio-Economic Objective (SEO) 2008: 920401 Behaviour and Health
920412 Preventive Medicine
Socio-Economic Objective (SEO) 2020: 200401 Behaviour and health
200412 Preventive medicine
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

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