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https://hdl.handle.net/1959.11/22395
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DC Field | Value | Language |
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dc.contributor.author | Dineen, J K | en |
dc.contributor.author | Gregg, Peter | en |
dc.contributor.author | Lascelles, A K | en |
dc.date.accessioned | 2018-01-23T09:56:00Z | - |
dc.date.issued | 1978 | - |
dc.identifier.citation | International Journal for Parasitology, 8(1), p. 59-63 | en |
dc.identifier.issn | 1879-0135 | en |
dc.identifier.issn | 0020-7519 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/22395 | - |
dc.description.abstract | The response of lambs to vaccination at weaning with irradiated 'Trichostrongylus colubriformis' larvae: segregation into 'responders' and 'non-responders'. International Journal for Parasitology 8: 59-63. Groups of colostrum fed and colostrum deprived lambs were vaccinated with irradiated 'Trichostrongylus colubriformis' larvae at weaning (3 months) and challenged with normal infective larvae. As there was no significant difference between the worm counts of these groups after challenge, it was concluded that the failure of lambs, generally, to respond to vaccination as vigorously as mature sheep, was not due to 'feed-back inhibition' of the immune response by the action of maternal antibody. However the results showed that the lambs segregated into 'responders' and 'non-responders'. The mean worm count of responders was 1560 whereas for non-responders this was 24,340. A responder was defined as an animal whose worm count was less than the lower limit of the 99 % confidence interval of unvaccinated controls. These results suggest that genetically-determined factors play an important role in the responsiveness of lambs to vaccination. Whereas counts of globule leucocytes in duodenal tissues were negatively correlated with worm counts (i.e. positively correlated with resistance), counts of both eosinophils and neutrophils were positively correlated with worm counts. These findings suggest that either globule leucocytes are involved in the resistance mechanism, or they are by-products of cellular events involved in resistance. On the other hand it is unlikely that either eosinophils or neutrophils are involved in the mechanism of resistance. | en |
dc.language | en | en |
dc.publisher | Elsevier Ltd | en |
dc.relation.ispartof | International Journal for Parasitology | en |
dc.title | The response of lambs to vaccination at weaning with irradiated 'Trichostrongylus colubriformis' larvae: Segregation into 'responders' and 'non-responders' | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/0020-7519(78)90052-8 | en |
dc.subject.keywords | Animal Protection (Pests and Pathogens) | en |
local.contributor.firstname | J K | en |
local.contributor.firstname | Peter | en |
local.contributor.firstname | A K | en |
local.subject.for2008 | 070205 Animal Protection (Pests and Pathogens) | en |
local.subject.seo2008 | 830311 Sheep - Wool | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.email | pgregg@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-chute-20171120-092606 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 59 | en |
local.format.endpage | 63 | en |
local.identifier.scopusid | 0018187484 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 8 | en |
local.identifier.issue | 1 | en |
local.title.subtitle | Segregation into 'responders' and 'non-responders' | en |
local.contributor.lastname | Dineen | en |
local.contributor.lastname | Gregg | en |
local.contributor.lastname | Lascelles | en |
dc.identifier.staff | une-id:pgregg | en |
local.profile.orcid | 0000-0001-7534-3567 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:22584 | en |
local.identifier.handle | https://hdl.handle.net/1959.11/22395 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | The response of lambs to vaccination at weaning with irradiated 'Trichostrongylus colubriformis' larvae | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Dineen, J K | en |
local.search.author | Gregg, Peter | en |
local.search.author | Lascelles, A K | en |
local.uneassociation | Unknown | en |
local.year.published | 1978 | en |
Appears in Collections: | Journal Article School of Environmental and Rural Science |
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