Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22395
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dc.contributor.authorDineen, J Ken
dc.contributor.authorGregg, Peteren
dc.contributor.authorLascelles, A Ken
dc.date.accessioned2018-01-23T09:56:00Z-
dc.date.issued1978-
dc.identifier.citationInternational Journal for Parasitology, 8(1), p. 59-63en
dc.identifier.issn1879-0135en
dc.identifier.issn0020-7519en
dc.identifier.urihttps://hdl.handle.net/1959.11/22395-
dc.description.abstractThe response of lambs to vaccination at weaning with irradiated 'Trichostrongylus colubriformis' larvae: segregation into 'responders' and 'non-responders'. International Journal for Parasitology 8: 59-63. Groups of colostrum fed and colostrum deprived lambs were vaccinated with irradiated 'Trichostrongylus colubriformis' larvae at weaning (3 months) and challenged with normal infective larvae. As there was no significant difference between the worm counts of these groups after challenge, it was concluded that the failure of lambs, generally, to respond to vaccination as vigorously as mature sheep, was not due to 'feed-back inhibition' of the immune response by the action of maternal antibody. However the results showed that the lambs segregated into 'responders' and 'non-responders'. The mean worm count of responders was 1560 whereas for non-responders this was 24,340. A responder was defined as an animal whose worm count was less than the lower limit of the 99 % confidence interval of unvaccinated controls. These results suggest that genetically-determined factors play an important role in the responsiveness of lambs to vaccination. Whereas counts of globule leucocytes in duodenal tissues were negatively correlated with worm counts (i.e. positively correlated with resistance), counts of both eosinophils and neutrophils were positively correlated with worm counts. These findings suggest that either globule leucocytes are involved in the resistance mechanism, or they are by-products of cellular events involved in resistance. On the other hand it is unlikely that either eosinophils or neutrophils are involved in the mechanism of resistance.en
dc.languageenen
dc.publisherElsevier Ltden
dc.relation.ispartofInternational Journal for Parasitologyen
dc.titleThe response of lambs to vaccination at weaning with irradiated 'Trichostrongylus colubriformis' larvae: Segregation into 'responders' and 'non-responders'en
dc.typeJournal Articleen
dc.identifier.doi10.1016/0020-7519(78)90052-8en
dc.subject.keywordsAnimal Protection (Pests and Pathogens)en
local.contributor.firstnameJ Ken
local.contributor.firstnamePeteren
local.contributor.firstnameA Ken
local.subject.for2008070205 Animal Protection (Pests and Pathogens)en
local.subject.seo2008830311 Sheep - Woolen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailpgregg@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20171120-092606en
local.publisher.placeUnited Kingdomen
local.format.startpage59en
local.format.endpage63en
local.identifier.scopusid0018187484en
local.peerreviewedYesen
local.identifier.volume8en
local.identifier.issue1en
local.title.subtitleSegregation into 'responders' and 'non-responders'en
local.contributor.lastnameDineenen
local.contributor.lastnameGreggen
local.contributor.lastnameLascellesen
dc.identifier.staffune-id:pgreggen
local.profile.orcid0000-0001-7534-3567en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:22584en
local.identifier.handlehttps://hdl.handle.net/1959.11/22395en
dc.identifier.academiclevelAcademicen
local.title.maintitleThe response of lambs to vaccination at weaning with irradiated 'Trichostrongylus colubriformis' larvaeen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorDineen, J Ken
local.search.authorGregg, Peteren
local.search.authorLascelles, A Ken
local.uneassociationUnknownen
local.year.published1978en
Appears in Collections:Journal Article
School of Environmental and Rural Science
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