Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22320
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dc.contributor.authorDuijvesteijn, Naomien
dc.contributor.authorVeltmaat, Jacqueline Men
dc.contributor.authorKnol, Egbert Fen
dc.contributor.authorHarlizius, Barbaraen
dc.date.accessioned2018-01-11T12:18:00Z-
dc.date.issued2014-
dc.identifier.citationBMC Genomics, v.15, p. 1-12en
dc.identifier.issn1471-2164en
dc.identifier.urihttps://hdl.handle.net/1959.11/22320-
dc.description.abstractBackground: Selection pressure on the number of teats has been applied to be able to provide enough teats for the increase in litter size in pigs. Although many QTL were reported, they cover large chromosomal regions and the functional mutations and their underlying biological mechanisms have not yet been identified. To gain a better insight in the genetic architecture of the trait number of teats, we performed a genome-wide association study by genotyping 936 Large White pigs using the Illumina PorcineSNP60 Beadchip. The analysis is based on deregressed breeding values to account for the dense family structure and a Bayesian approach for estimation of the SNP effects. Results: The genome-wide association study resulted in 212 significant SNPs. In total, 39 QTL regions were defined including 170 SNPs on 13 'Sus scrofa' chromosomes (SSC) of which 5 regions on SSC7, 9, 10, 12 and 14 were highly significant. All significantly associated regions together explain 9.5% of the genetic variance where a QTL on SSC7 explains the most genetic variance (2.5%). For the five highly significant QTL regions, a search for candidate genes was performed. The most convincing candidate genes were VRTN and Prox2 on SSC7, MPP7, ARMC4, and MKX on SSC10, and vertebrae δ-EF1 on SSC12. All three QTL contain candidate genes which are known to be associated with vertebral development. In the new QTL regions on SSC9 and SSC14, no obvious candidate genes were identified. Conclusions: Five major QTL were found at high resolution on SSC7, 9, 10, 12, and 14 of which the QTL on SSC9 and SSC14 are the first ones to be reported on these chromosomes. The significant SNPs found in this study could be used in selection to increase number of teats in pigs, so that the increasing number of live-born piglets can be nursed by the sow. This study points to common genetic mechanisms regulating number of vertebrae and number of teats.en
dc.languageenen
dc.publisherBioMed Central Ltden
dc.relation.ispartofBMC Genomicsen
dc.titleHigh-resolution association mapping of number of teats in pigs reveals regions controlling vertebral developmenten
dc.typeJournal Articleen
dc.identifier.doi10.1186/1471-2164-15-542en
dcterms.accessRightsGolden
dc.subject.keywordsAnimal Growth and Developmenten
dc.subject.keywordsAnimal Reproductionen
dc.subject.keywordsAnimal Breedingen
local.contributor.firstnameNaomien
local.contributor.firstnameJacqueline Men
local.contributor.firstnameEgbert Fen
local.contributor.firstnameBarbaraen
local.subject.for2008070201 Animal Breedingen
local.subject.for2008070202 Animal Growth and Developmenten
local.subject.for2008070206 Animal Reproductionen
local.subject.seo2008830308 Pigsen
local.subject.seo2008830399 Livestock Raising not elsewhere classifieden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailnduijves@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20180111-10241en
local.publisher.placeUnited Kingdomen
local.identifier.runningnumber542en
local.format.startpage1en
local.format.endpage12en
local.peerreviewedYesen
local.identifier.volume15en
local.access.fulltextYesen
local.contributor.lastnameDuijvesteijnen
local.contributor.lastnameVeltmaaten
local.contributor.lastnameKnolen
local.contributor.lastnameHarliziusen
dc.identifier.staffune-id:nduijvesen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:22509en
local.identifier.handlehttps://hdl.handle.net/1959.11/22320en
dc.identifier.academiclevelAcademicen
local.title.maintitleHigh-resolution association mapping of number of teats in pigs reveals regions controlling vertebral developmenten
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorDuijvesteijn, Naomien
local.search.authorVeltmaat, Jacqueline Men
local.search.authorKnol, Egbert Fen
local.search.authorHarlizius, Barbaraen
local.uneassociationUnknownen
local.year.published2014en
local.subject.for2020300109 Non-genetically modified uses of biotechnologyen
local.subject.for2020300301 Animal growth and developmenten
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.seo2020100410 Pigsen
Appears in Collections:Journal Article
School of Environmental and Rural Science
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