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Title: Genomic analysis reveals selection for Asian genes in European pigs following human-mediated introgression
Contributor(s): Bosse, Mirte (author); Megens, Hendrik-Jan (author); Groenen, Martien A M (author); Frantz, Laurent A F (author); Madsen, Ole (author); Larson, Greger (author); Paudel, Yogesh (author); Duijvesteijn, Naomi  (author); Harlizius, Barbara (author); Hagemeijer, Yanick (author); Crooijmans, Richard P M A (author)
Publication Date: 2014
Open Access: Yes
DOI: 10.1038/ncomms5392Open Access Link
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Abstract: The independent domestication of local wild boar populations in Asia and Europe about 10,000 years ago led to distinct European and Asian pig breeds, each with very different phenotypic characteristics. During the Industrial Revolution, Chinese breeds were imported to Europe to improve commercial traits in European breeds. Here we demonstrate the presence of introgressed Asian haplotypes in European domestic pigs and selection signatures on some loci in these regions, using whole genome sequence data. The introgression signatures are widespread and the Asian haplotypes are rarely fixed. The Asian introgressed haplotypes are associated with regions harbouring genes involved in meat quality, development and fertility. We identify Asian-derived non-synonymous mutations in the AHR gene that associate with increased litter size in multiple European commercial lines. These findings demonstrate that increased fertility was an important breeding goal for early nineteenth century pig farmers, and that Asian variants of genes related to this trait were preferentially selected during the development of modern European pig breeds.
Publication Type: Journal Article
Source of Publication: Nature Communications, v.5, p. 1-8
Publisher: Nature Publishing Group
Place of Publication: United Kingdom
ISSN: 2041-1723
Field of Research (FOR): 070206 Animal Reproduction
070201 Animal Breeding
070299 Animal Production not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Environmental and Rural Science

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