Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/22213
Title: | The effect of age on the response of sheep to vaccination with irradiated 'trichostrongylus colubriformis' larvae | Contributor(s): | Gregg, Peter (author) ; Dineen, J K (author); Rothwell, T L W (author); Kelly, J D (author) | Publication Date: | 1978 | DOI: | 10.1016/0304-4017(78)90034-1 | Handle Link: | https://hdl.handle.net/1959.11/22213 | Abstract: | Vaccination with irradiated 'Trichostrongylus colubriformis' larvae produced a high level of immunity, as judged by faecal egg counts and worm burdens following challenge with normal larvae, in nine of ten sheep aged 10 months. In lambs aged 3 months, vaccination was less effective. Some lambs developed partial immunity, b u t others did not respond. Serum levels of antibodies to 'T. colubriformis' acetylcholinesterase reflected the extent of antigenic exposure rather than the degree of immunity acquired, and there was no evidence that the unresponsiveness of the lambs was due to a deficiency in antibody production. Unresponsiveness was not associated with the numbers of circulating lymphocytes, monocytes or granulocytes, or with the numbers of mast cells, eosinophils and neutrophils at the site of infection. However, there were many globule leucocytes in the intestinal mucosa of adult sheep which were resistant to challenge infection. On the other hand, few of these cells were found in vaccinated lambs which generally gave a poor response to challenge. | Publication Type: | Journal Article | Source of Publication: | Veterinary Parasitology, 4(1), p. 35-48 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1873-2550 0304-4017 |
Fields of Research (FoR) 2008: | 070205 Animal Protection (Pests and Pathogens) | Socio-Economic Objective (SEO) 2008: | 830311 Sheep - Wool | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
---|---|
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
SCOPUSTM
Citations
52
checked on Feb 24, 2024
Page view(s)
1,282
checked on Oct 29, 2023
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.