Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22213
Title: The effect of age on the response of sheep to vaccination with irradiated 'trichostrongylus colubriformis' larvae
Contributor(s): Gregg, Peter (author)orcid ; Dineen, J K (author); Rothwell, T L W (author); Kelly, J D (author)
Publication Date: 1978
DOI: 10.1016/0304-4017(78)90034-1
Handle Link: https://hdl.handle.net/1959.11/22213
Abstract: Vaccination with irradiated 'Trichostrongylus colubriformis' larvae produced a high level of immunity, as judged by faecal egg counts and worm burdens following challenge with normal larvae, in nine of ten sheep aged 10 months. In lambs aged 3 months, vaccination was less effective. Some lambs developed partial immunity, b u t others did not respond. Serum levels of antibodies to 'T. colubriformis' acetylcholinesterase reflected the extent of antigenic exposure rather than the degree of immunity acquired, and there was no evidence that the unresponsiveness of the lambs was due to a deficiency in antibody production. Unresponsiveness was not associated with the numbers of circulating lymphocytes, monocytes or granulocytes, or with the numbers of mast cells, eosinophils and neutrophils at the site of infection. However, there were many globule leucocytes in the intestinal mucosa of adult sheep which were resistant to challenge infection. On the other hand, few of these cells were found in vaccinated lambs which generally gave a poor response to challenge.
Publication Type: Journal Article
Source of Publication: Veterinary Parasitology, 4(1), p. 35-48
Publisher: Elsevier BV
Place of Publication: The Netherlands
ISSN: 1873-2550
0304-4017
Field of Research (FOR): 070205 Animal Protection (Pests and Pathogens)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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