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|Title:||Failure to Induce Homologus Immunity to ‘Fasciola Hepatica’ in Sheep Vaccinated With Irradiated Metacercariae||Contributor(s):||Campbell, N J (author); Gregg, Peter (author) ; Kelly, J D (author); Dineen, J K (author)||Publication Date:||1978||DOI:||10.1016/0304-4017(78)90005-5||Handle Link:||https://hdl.handle.net/1959.11/22212||Abstract:||Vaccination of sheep with either 100 or 1000 γ-irradiated (2.5 krad) metacercariae of Fasciola hepatica, on two occasions six weeks apart, did not generate significant protection against intraruminal challenge with F. 'hepatica' six weeks after the second vaccinating dose as measured by recovery of flukes from liver and bile ducts, twenty weeks after challenge. There was, however, a significant increase in the proportion of flukes retarded in the parenchyma of both vaccinated groups. The percentage of retarded flukes was positively correlated with the degree of liver damage and increased weight of the hepatic lymph nodes. It was not possible to determine if the retarded flukes were derived from the vaccine or challenge infections or both. Challenge infection of both vaccinated and unvaccinated sheep significantly increased the numbers of eosinophils and globule leucocytes in the parenchymal bile duct and the numbers of mast cells and globule leucocytes in the abdominal bile duct. In addition the numbers of eosinophils and globule leucocytes in the parenchymal bile duct were significantly correlated with the percentage of retarded flukes in both vaccinated groups. In the abdominal bile duct, only the numbers of eosinophils in the low level vaccination group were significantly correlated with fluke retardation. Vaccination did not protect against the pathogenic effects of challenge infection as measured by reduced packed cell volumes and weight gain.||Publication Type:||Journal Article||Source of Publication:||Veterinary Parasitology, 4(2), p. 143-152||Publisher:||Elsevier BV||Place of Publication:||The Netherlands||ISSN:||1873-2550
|Field of Research (FOR):||070205 Animal Protection (Pests and Pathogens)||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 15
|Appears in Collections:||Journal Article|
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