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Muller-Nurasyid, Martina

Ngwa, Julius S

Nolte, Ilja M

Paternoster, Lavinia

Pechlivanis, Sonali

Perola, Markus

Justice, Anne E

Peters, Marjolein J

Preuss, Michael

Rose, Lynda M

Shi, Jianxin

Shungin, Dmitry

Smith, Albert Vernon

Strawbridge, Rona J

Surakka, Ida

Teumer, Alexander

Trip, Mieke D

Monda, Keri L

Tyrer, Jonathan

Van Vliet-Ostaptchouk, Jana V

Vandenput, Liesbeth

Waite, Lindsay L

Zhao, Jing Hua

Absher, Devin

Asselbergs, Folkert W

Atalay, Mustafa

Attwood, Antony P

Balmforth, Anthony J

Croteau-Chonka, Damien C

Basart, Hanneke

Beilby, John

Bonnycastle, Lori L

Brambilla, Paolo

Bruinenberg, Marcel

Campbell, Harry

Chasman, Daniel I

Chines, Peter S

Collins, Francis S

Connell, John M

Day, Felix R

Cookson, William O

de Faire, Ulf

de Vegt, Femmie

Dei, Mariano

Dimitriou, Maria

Edkins, Sarah

Estrada, Karol

Evans, David M

Farrall, Martin

Ferrario, Marco M

2013

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.

Nature Genetics, 45(5), p. 501-512

1546-1718

1061-4036

https://hdl.handle.net/1959.11/22075

en

Nature Publishing Group

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Journal Article

Publication