Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

2013

Berndt, Sonja I

Gustafsson, Stefan

Esko, Tonu

Ferrieres, Jean

Franke, Lude

Frau, Francesca

Gejman, Pablo V

Grallert, Harald

Gronberg, Henrik

Gudnason, Vilmundur

Hall, Alistair S

Hall, Per

Hartikainen, Anna-Liisa

Fall, Tove

Hayward, Caroline

Heard-Costa, Nancy L

Heath, Andrew C

Hebebrand, Johannes

Homuth, Georg

Hu, Frank B

Hunt, Sarah E

Hypponen, Elina

Iribarren, Carlos

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Jansson, John-Olov

Jula, Antti

Kahonen, Mika

Kathiresan, Sekar

Kee, Frank

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Kivimaki, Mika

Koenig, Wolfgang

Kraja, Aldi T

Kumari, Meena

Gentilini, Davide

Kuulasmaa, Kari

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Laitinen, Jaana H

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Langenberg, Claudia

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Marz, Winfried

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Luan, Jian'an

Mihailov, Evelin

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Narisu, Narisu

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Palotie, Aarno

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Pouta, Anneli

Vedantam, Sailaja

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Putter, Carolin

Radhakrishnan, Aparna

Raitakari, Olli

Rendon, Augusto

Rivadeneira, Fernando

Rudan, Igor

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Sambrook, Jennifer G

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Saramies, Jouko

Schipf, Sabine

Schreiber, Stefan

Schunkert, Heribert

Shin, So-Youn

Signorini, Stefano

Sinisalo, Juha

Skrobek, Boris

Winkler, Thomas W

Soranzo, Nicole

Stancakova, Alena

Stark, Klaus

Stephens, Jonathan C

Stirrups, Kathleen

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Stumvoll, Michael

Swift, Amy J

Theodoraki, Eirini V

Thorand, Barbara

Magi, Reedik

Wood, Andrew R

Tregouet, David-Alexandre

Tremoli, Elena

Van der Klauw, Melanie M

van Meurs, Joyce B J

Vermeulen, Sita H

Viikari, Jorma

Virtamo, Jarmo

Vitart, Veronique

Waeber, Gerard

Wang, Zhaoming

Workalemahu, Tsegaselassie

Widen, Elisabeth

Wild, Sarah H

Willemsen, Gonneke

Winkelmann, Bernhard R

Witteman, Jacqueline C M

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Wright, Alan F

Zillikens, M Carola

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Hu, Yi-Juan

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Chanock, Stephen J

Cupples, L Adrienne

Cusi, Daniele

Dedoussis, George V

Erdmann, Jeanette

Eriksson, Johan G

Lee, Sang Hong

Franks, Paul W

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Gieger, Christian

Gyllensten, Ulf

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Hengstenberg, Christian

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Hingorani, Aroon

Hinney, Anke

Liang, Liming

Hofman, Albert

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Jarvelin, Marjo-Riitta

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Keinanen-Kiukaanniemi, Sirkka M

Kiemeney, Lambertus A

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Laakso, Markku

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Lehtimaki, Terho

Levinson, Douglas F

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Metspalu, Andres

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Thorsteinsdottir, Unnur

van Duijn, Cornelia M

Amin, Najaf

Visscher, Peter M

Di Blasio, Anna Maria

Hirschhorn, Joel N

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Morris, Andrew P

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Bragg-Gresham, Jennifer L

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Cadby, Gemma

den Heijer, Martin

Eklund, Niina

Fischer, Krista

Goel, Anuj

Hottenga, Jouke-Jan

Huffman, Jennifer E

Wheeler, Eleanor

Jarick, Ivonne

Johansson, Asa

Johnson, Toby

Kanoni, Stavroula

Kleber, Marcus E

Konig, Inke R

Kristiansson, Kati

Kutalik, Zoltan

Lamina, Claudia

Lecoeur, Cecile

Feitosa, Mary F

Li, Guo

Mangino, Massimo

McArdle, Wendy L

Medina-Gomez, Carolina

Muller-Nurasyid, Martina

Ngwa, Julius S

Nolte, Ilja M

Paternoster, Lavinia

Pechlivanis, Sonali

Perola, Markus

Justice, Anne E

Peters, Marjolein J

Preuss, Michael

Rose, Lynda M

Shi, Jianxin

Shungin, Dmitry

Smith, Albert Vernon

Strawbridge, Rona J

Surakka, Ida

Teumer, Alexander

Trip, Mieke D

Monda, Keri L

Tyrer, Jonathan

Van Vliet-Ostaptchouk, Jana V

Vandenput, Liesbeth

Waite, Lindsay L

Zhao, Jing Hua

Absher, Devin

Asselbergs, Folkert W

Atalay, Mustafa

Attwood, Antony P

Balmforth, Anthony J

Croteau-Chonka, Damien C

Basart, Hanneke

Beilby, John

Bonnycastle, Lori L

Brambilla, Paolo

Bruinenberg, Marcel

Campbell, Harry

Chasman, Daniel I

Chines, Peter S

Collins, Francis S

Connell, John M

Day, Felix R

Cookson, William O

de Faire, Ulf

de Vegt, Femmie

Dei, Mariano

Dimitriou, Maria

Edkins, Sarah

Estrada, Karol

Evans, David M

Farrall, Martin

Ferrario, Marco M

Journal Article

en

Publication

Nature Publishing Group

United States of America

10.1038/ng.2606

une:22265

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.

link

Nature Genetics, 45(5), p. 501-512

1546-1718

1061-4036

501

512