Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22075
Title: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Contributor(s): Berndt, Sonja I (author); Gustafsson, Stefan (author); Esko, Tonu (author); Ferrieres, Jean (author); Franke, Lude (author); Frau, Francesca (author); Gejman, Pablo V (author); Grallert, Harald (author); Gronberg, Henrik (author); Gudnason, Vilmundur (author); Hall, Alistair S (author); Hall, Per (author); Hartikainen, Anna-Liisa (author); Fall, Tove (author); Hayward, Caroline (author); Heard-Costa, Nancy L (author); Heath, Andrew C (author); Hebebrand, Johannes (author); Homuth, Georg (author); Hu, Frank B (author); Hunt, Sarah E (author); Hypponen, Elina (author); Iribarren, Carlos (author); Jacobs, Kevin B (author); Ferreira, Teresa (author); Jansson, John-Olov (author); Jula, Antti (author); Kahonen, Mika (author); Kathiresan, Sekar (author); Kee, Frank (author); Khaw, Kay-Tee (author); Kivimaki, Mika (author); Koenig, Wolfgang (author); Kraja, Aldi T (author); Kumari, Meena (author); Gentilini, Davide (author); Kuulasmaa, Kari (author); Kuusisto, Johanna (author); Laitinen, Jaana H (author); Lakka, Timo A (author); Langenberg, Claudia (author); Launer, Lenore J (author); Lind, Lars (author); Lindstrom, Jaana (author); Liu, Jianjun (author); Liuzzi, Antonio (author); Jackson, Anne U (author); Lokki, Marja-Liisa (author); Lorentzon, Mattias (author); Madden, Pamela A (author); Magnusson, Patrik K (author); Manunta, Paolo (author); Marek, Diana (author); Marz, Winfried (author); Leach, Irene Mateo (author); McKnight, Barbara (author); Medland, Sarah E (author); Luan, Jian'an (author); Mihailov, Evelin (author); Milani, Lili (author); Montgomery, Grant W (author); Mooser, Vincent (author); Muhleisen, Thomas W (author); Munroe, Patricia B (author); Musk, Arthur W (author); Narisu, Narisu (author); Navis, Gerjan (author); Nicholson, George (author); Randall, Joshua C (author); Nohr, Ellen A (author); Ong, Ken K (author); Oostra, Ben A (author); Palmer, Colin N A (author); Palotie, Aarno (author); Peden, John F (author); Pedersen, Nancy (author); Peters, Annette (author); Polasek, Ozren (author); Pouta, Anneli (author); Vedantam, Sailaja (author); Pramstaller, Peter P (author); Prokopenko, Inga (author); Putter, Carolin (author); Radhakrishnan, Aparna (author); Raitakari, Olli (author); Rendon, Augusto (author); Rivadeneira, Fernando (author); Rudan, Igor (author); Saaristo, Timo E (author); Sambrook, Jennifer G (author); Willer, Cristen J (author); Sanders, Alan R (author); Sanna, Serena (author); Saramies, Jouko (author); Schipf, Sabine (author); Schreiber, Stefan (author); Schunkert, Heribert (author); Shin, So-Youn (author); Signorini, Stefano (author); Sinisalo, Juha (author); Skrobek, Boris (author); Winkler, Thomas W (author); Soranzo, Nicole (author); Stancakova, Alena (author); Stark, Klaus (author); Stephens, Jonathan C (author); Stirrups, Kathleen (author); Stolk, Ronald P (author); Stumvoll, Michael (author); Swift, Amy J (author); Theodoraki, Eirini V (author); Thorand, Barbara (author); Magi, Reedik (author); Wood, Andrew R (author); Tregouet, David-Alexandre (author); Tremoli, Elena (author); Van der Klauw, Melanie M (author); van Meurs, Joyce B J (author); Vermeulen, Sita H (author); Viikari, Jorma (author); Virtamo, Jarmo (author); Vitart, Veronique (author); Waeber, Gerard (author); Wang, Zhaoming (author); Workalemahu, Tsegaselassie (author); Widen, Elisabeth (author); Wild, Sarah H (author); Willemsen, Gonneke (author); Winkelmann, Bernhard R (author); Witteman, Jacqueline C M (author); Wolffenbuttel, Bruce H R (author); Wong, Andrew (author); Wright, Alan F (author); Zillikens, M Carola (author); Amouyel, Philippe (author); Hu, Yi-Juan (author); Boehm, Bernhard O (author); Boerwinkle, Eric (author); Boomsma, Dorret I (author); Caulfield, Mark J (author); Chanock, Stephen J (author); Cupples, L Adrienne (author); Cusi, Daniele (author); Dedoussis, George V (author); Erdmann, Jeanette (author); Eriksson, Johan G (author); Lee, Sang Hong  (author); Franks, Paul W (author); Froguel, Philippe (author); Gieger, Christian (author); Gyllensten, Ulf (author); Hamsten, Anders (author); Harris, Tamara B (author); Hengstenberg, Christian (author); Hicks, Andrew A (author); Hingorani, Aroon (author); Hinney, Anke (author); Liang, Liming (author); Hofman, Albert (author); Hovingh, Kees G (author); Hveem, Kristian (author); Illig, Thomas (author); Jarvelin, Marjo-Riitta (author); Jockel, Karl-Heinz (author); Keinanen-Kiukaanniemi, Sirkka M (author); Kiemeney, Lambertus A (author); Kuh, Diana (author); Laakso, Markku (author); Lin, Dan-Yu (author); Lehtimaki, Terho (author); Levinson, Douglas F (author); Martin, Nicholas G (author); Metspalu, Andres (author); Morris, Andrew D (author); Nieminen, Markku S (author); Njolstad, Inger (author); Ohlsson, Claes (author); Oldehinkel, Albertine J (author); Ouwehand, Willem H (author); Min, Josine L (author); Palmer, Lyle J (author); Penninx, Brenda (author); Power, Chris (author); Province, Michael A (author); Psaty, Bruce M (author); Qi, Lu (author); Rauramaa, Rainer (author); Ridker, Paul M (author); Ripatti, Samuli (author); Salomaa, Veikko (author); Neale, Benjamin M (author); Samani, Nilesh J (author); Snieder, Harold (author); Sorensen, Thorkild I A (author); Spector, Timothy D (author); Stefansson, Kari (author); Tonjes, Anke (author); Tuomilehto, Jaakko (author); Uitterlinden, Andre G (author); Uusitupa, Matti (author); van der Harst, Pim (author); Thorleifsson, Gudmar (author); Vollenweider, Peter (author); Wallaschofski, Henri (author); Wareham, Nicholas J (author); Watkins, Hugh (author); Wichmann, H-Erich (author); Wilson, James F (author); Abecasis, Goncalo R (author); Assimes, Themistocles L (author); Barroso, Ines (author); Boehnke, Michael (author); Yang, Jian (author); Borecki, Ingrid B (author); Deloukas, Panos (author); Fox, Caroline S (author); Frayling, Timothy (author); Groop, Leif C (author); Haritunian, Talin (author); Heid, Iris M (author); Hunter, David (author); Kaplan, Robert C (author); Karpe, Fredrik (author); Ganna, Andrea (author); Albrecht, Eva (author); Moffatt, Miriam F (author); Mohlke, Karen L (author); O'Connell, Jeffrey R (author); Pawitan, Yudi (author); Schadt, Eric E (author); Schlessinger, David (author); Steinthorsdottir, Valgerdur (author); Strachan, David P (author); Thorsteinsdottir, Unnur (author); van Duijn, Cornelia M (author); Amin, Najaf (author); Visscher, Peter M (author); Di Blasio, Anna Maria (author); Hirschhorn, Joel N (author); Lindgren, Cecilia M (author); Morris, Andrew P (author); Meyre, David (author); Scherag, Andre (author); McCarthy, Mark I (author); Speliotes, Elizabeth K (author); North, Kari E (author); Bragg-Gresham, Jennifer L (author); Loos, Ruth J F (author); Ingelsson, Erik (author); Cadby, Gemma (author); den Heijer, Martin (author); Eklund, Niina (author); Fischer, Krista (author); Goel, Anuj (author); Hottenga, Jouke-Jan (author); Huffman, Jennifer E (author); Wheeler, Eleanor (author); Jarick, Ivonne (author); Johansson, Asa (author); Johnson, Toby (author); Kanoni, Stavroula (author); Kleber, Marcus E (author); Konig, Inke R (author); Kristiansson, Kati (author); Kutalik, Zoltan (author); Lamina, Claudia (author); Lecoeur, Cecile (author); Feitosa, Mary F (author); Li, Guo (author); Mangino, Massimo (author); McArdle, Wendy L (author); Medina-Gomez, Carolina (author); Muller-Nurasyid, Martina (author); Ngwa, Julius S (author); Nolte, Ilja M (author); Paternoster, Lavinia (author); Pechlivanis, Sonali (author); Perola, Markus (author); Justice, Anne E (author); Peters, Marjolein J (author); Preuss, Michael (author); Rose, Lynda M (author); Shi, Jianxin (author); Shungin, Dmitry (author); Smith, Albert Vernon (author); Strawbridge, Rona J (author); Surakka, Ida (author); Teumer, Alexander (author); Trip, Mieke D (author); Monda, Keri L (author); Tyrer, Jonathan (author); Van Vliet-Ostaptchouk, Jana V (author); Vandenput, Liesbeth (author); Waite, Lindsay L (author); Zhao, Jing Hua (author); Absher, Devin (author); Asselbergs, Folkert W (author); Atalay, Mustafa (author); Attwood, Antony P (author); Balmforth, Anthony J (author); Croteau-Chonka, Damien C (author); Basart, Hanneke (author); Beilby, John (author); Bonnycastle, Lori L (author); Brambilla, Paolo (author); Bruinenberg, Marcel (author); Campbell, Harry (author); Chasman, Daniel I (author); Chines, Peter S (author); Collins, Francis S (author); Connell, John M (author); Day, Felix R (author); Cookson, William O (author); de Faire, Ulf (author); de Vegt, Femmie (author); Dei, Mariano (author); Dimitriou, Maria (author); Edkins, Sarah (author); Estrada, Karol (author); Evans, David M (author); Farrall, Martin (author); Ferrario, Marco M (author)
Publication Date: 2013
Open Access: Yes
DOI: 10.1038/ng.2606Open Access Link
Handle Link: https://hdl.handle.net/1959.11/22075
Open Access Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973018/Open Access Link
Abstract: Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Publication Type: Journal Article
Source of Publication: Nature Genetics, 45(5), p. 501-512
Publisher: Nature Publishing Group
Place of Publication: United States of America
ISSN: 1061-4036
1546-1718
Field of Research (FOR): 060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Socio-Economic Outcome Codes: 920110 Inherited Diseases (incl. Gene Therapy)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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