Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

2013

Lee, Sang Hong

Ripke, Stephan

Absher, Devin

Freedman, Robert

Freimer, Nelson B

Freitag, Christine M

Friedl, Marion

Frisen, Louise

Gallagher, Louise

Gejman, Pablo V

Georgieva, Lyudmila

Gershon, Elliot S

Geschwind, Daniel H

Agartz, Ingrid

Giegling, Ina

Gill, Michael

Gordon, Scott D

Gordon-Smith, Katherine

Green, Elaine K

Greenwood, Tiffany A

Grice, Dorothy E

Gross, Magdalena

Grozeva, Detelina

Guan, Weihua

Akil, Huda

Gurling, Hugh

De Haan, Lieuwe

Haines, Jonathan L

Hakonarson, Hakon

Hallmayer, Joachim

Hamilton, Steven P

Hamshere, Marian L

Hansen, Thomas F

Hartmann, Annette M

Hautzinger, Martin

Amin, Farooq

Heath, Andrew C

Henders, Anjali K

Herms, Stefan

Hickie, Ian B

Hipolito, Maria

Hoefels, Susanne

Holmans, Peter A

Holsboer, Florian

Hoogendijk, Witte J

Hottenga, Jouke-Jan

Andreassen, Ole A

Hultman, Christina M

Hus, Vanessa

Ingason, Andres

Ising, Marcus

Jamain, Stephane

Jones, Edward G

Jones, Ian

Jones, Lisa

Tzeng, Jung-Ying

Kahler, Anna K

Anjorin, Adebayo

Kahn, Rene S

Kandaswamy, Radhika

Keller, Matthew C

Kennedy, James L

Kenny, Elaine

Kent, Lindsey

Kim, Yunjung

Kirov, George K

Klauck, Sabine M

Klei, Lambertus

Anney, Richard

Knowles, James A

Kohli, Martin A

Koller, Daniel L

Konte, Bettina

Korszun, Ania

Krabbendam, Lydia

Krasucki, Robert

Kuntsi, Jonna

Kwan, Phoenix

Landen, Mikael

Anttila, Verneri

Langstrom, Niklas

Lathrop, Mark

Lawrence, Jacob

Lawson, William B

Leboyer, Marion

Ledbetter, David H

Lee, Phil H

Lencz, Todd

Lesch, Klaus-Peter

Levinson, Douglas F

Arking, Dan E

Lewis, Cathryn M

Li, Jun

Lichtenstein, Paul

Lieberman, Jeffrey A

Lin, Dan-Yu

Linszen, Don H

Liu, Chunyu

Lohoff, Falk W

Loo, Sandra K

Lord, Catherine

Asherson, Philip

Lowe, Jennifer K

Lucae, Susanne

MacIntyre, Donald J

Madden, Pamela A F

Maestrini, Elena

Magnusson, Patrik K E

Mahon, Pamela B

Maier, Wolfgang

Malhotra, Anil K

Mane, Shrikant M

Neale, Benjamin M

Azevedo, Maria H

Martin, Christa L

Martin, Nicholas G

Mattheisen, Manuel

Matthews, Keith

Mattingsdal, Morten

McCarroll, Steven A

McGhee, Kevin A

McGough, James J

McGrath, Patrick J

McGuffin, Peter

Backlund, Lena

McInnis, Melvin G

McIntosh, Andrew

McKinney, Rebecca

McLean, Alan W

McMahon, Francis J

McMahon, William M

McQuillin, Andrew

Medeiros, Helena

Medland, Sarah E

Meier, Sandra

Badner, Judith A

Melle, Ingrid

Meng, Fan

Meyer, Jobst

Middeldorp, Christel M

Middleton, Lefkos

Milanova, Vihra

Miranda, Ana

Monaco, Anthony P

Montgomery, Grant W

Moran, Jennifer L

Bailey, Anthony J

Moreno-De-Luca, Daniel

Morken, Gunnar

Morris, Derek W

Morrow, Eric M

Moskvina, Valentina

Muglia, Pierandrea

Muhleisen, Thomas W

Muir, Walter J

Muller-Myhsok, Bertram

Murtha, Michael

Banaschewski, Tobias

Myers, Richard M

Myin-Germeys, Inez

Neale, Michael C

Nelson, Stan F

Nievergelt, Caroline M

Nikolov, Ivan

Nimgaonkar, Vishwajit

Nolen, Willem A

Nothen, Markus M

Nurnberger, John I

Barchas, Jack D

Nwulia, Evaristus A

Nyholt, Dale R

O'Dushlaine, Colm

Oades, Robert D

Olincy, Ann

Oliveira, Guiomar

Olsen, Line

Ophoff, Roel A

Osby, Urban

Owen, Michael J

Barnes, Michael R

Palotie, Aarno

Parr, Jeremy R

Paterson, Andrew D

Pato, Carlos N

Pato, Michele T

Penninx, Brenda W

Pergadia, Michele L

Pericak-Vance, Margaret A

Pickard, Benjamin S

Pimm, Jonathan

Barrett, Thomas B

Piven, Joseph

Posthuma, Danielle

Potash, James B

Poustka, Fritz

Propping, Peter

Puri, Vinay

Quested, Digby J

Quinn, Emma M

Ramos-Quiroga, Josep Antoni

Rasmussen, Henrik B

Bass, Nicholas

Raychaudhuri, Soumya

Rehnstrom, Karola

Reif, Andreas

Ribases, Marta

Rice, John P

Rietschel, Marcella

Roeder, Kathryn

Roeyers, Herbert

Rossin, Lizzy

Rothenberger, Aribert

Battaglia, Agatino

Rouleau, Guy

Ruderfer, Douglas

Rujescu, Dan

Sanders, Alan R

Sanders, Stephan J

Santangelo, Susan L

Sergeant, Joseph A

Schachar, Russell

Schalling, Martin

Schatzberg, Alan F

Faraone, Stephen V

Bauer, Michael

Scheftner, William A

Schellenberg, Gerard D

Scherer, Stephen W

Schork, Nicholas J

Schulze, Thomas G

Schumacher, Johannes

Schwarz, Markus

Scolnick, Edward

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Bayes, Monica

Shilling, Paul D

Shyn, Stanley I

Silverman, Jeremy M

Slager, Susan L

Smalley, Susan L

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Smith, Erin N

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St. Clair, David

State, Matthew

Bellivier, Frank

Steffens, Michael

Steinhausen, Hans-Christoph

Strauss, John S

Strohmaier, Jana

Stroup, T Scott

Sutcliffe, James S

Szatmari, Peter

Szelinger, Szabocls

Thirumalai, Srinivasa

Thompson, Robert C

Bergen, Sarah E

Todorov, Alexandre A

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Treutlein, Jens

Uhr, Manfred

van den Oord, Edwin J C G

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Van Os, Jim

Vicente, Astrid M

Vieland, Veronica J

Vincent, John B

Berrettini, Wade

Visscher, Peter M

Walsh, Christopher A

Wassink, Thomas H

Watson, Stanley J

Weissman, Myrna M

Werge, Thomas

Wienker, Thomas F

Wijsman, Ellen M

Willemsen, Gonneke

Williams, Nigel

Betancur, Catalina

Willsey, A Jeremy

Witt, Stephanie H

Xu, Wei

Young, Allan H

Yu, Timothy W

Zammit, Stanley

Zandi, Peter P

Zhang, Peng

Zitman, Frans G

Zollner, Sebastian

Bettecken, Thomas

Devlin, Bernie

Kelsoe, John R

Sklar, Pamela

Daly, Mark J

O'Donovan, Michael C

Craddock, Nicholas

Sullivan, Patrick F

Smoller, Jordan W

Kendler, Kenneth S

Wray, Naomi R

Biederman, Joseph

Binder, Elisabeth B

Black, Donald W

Purcell, Shaun M

Blackwood, Douglas H R

Bloss, Cinnamon S

Boehnke, Michael

Boomsma, Dorret I

Breen, Gerome

Breuer, Rene

Bruggeman, Richard

Cormican, Paul

Buccola, Nancy G

Buitelaar, Jan K

Perlis, Roy H

Bunney, William E

Buxbaum, Joseph D

Byerley, William F

Byrne, Enda M

Caesar, Sian

Cahn, Wiepke

Cantor, Rita M

Casas, Miguel

Chakravarti, Aravinda

Chambert, Kimberly

Mowry, Bryan J

Choudhury, Khalid

Cichon, Sven

Cloninger, C Robert

Collier, David A

Cook, Edwin H

Coon, Hilary

Cormand, Bru

Corvin, Aiden

Coryell, William H

Craig, David W

Thapar, Anita

Craig, Ian W

Crosbie, Jennifer

Cuccaro, Michael L

Curtis, David

Czamara, Darina

Datta, Susmita

Dawson, Geraldine

Day, Richard

De Geus, Eco J

Degenhardt, Franziska

Goddard, Michael E

Djurovic, Srdjan

Donohoe, Gary J

Doyle, Alysa E

Duan, Jubao

Dudbridge, Frank

Duketis, Eftichia

Ebstein, Richard P

Edenberg, Howard J

Elia, Josephine

Ennis, Sean

Witte, John S

Etain, Bruno

Fanous, Ayman

Farmer, Anne E

Ferrier, I Nicol

Flickinger, Matthew

Fombonne, Eric

Foroud, Tatiana

Frank, Josef

Franke, Barbara

Fraser, Christine

Journal Article

en

Publication

Nature Publishing Group

United States of America

10.1038/ng.2711

une:22256

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.c.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

link

Nature Genetics, 45(9), p. 984-994

1546-1718

1061-4036

984

994