Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22066
Title: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Contributor(s): Lee, Sang Hong  (author); Ripke, Stephan (author); Absher, Devin (author); Freedman, Robert (author); Freimer, Nelson B (author); Freitag, Christine M (author); Friedl, Marion (author); Frisen, Louise (author); Gallagher, Louise (author); Gejman, Pablo V (author); Georgieva, Lyudmila (author); Gershon, Elliot S (author); Geschwind, Daniel H (author); Agartz, Ingrid (author); Giegling, Ina (author); Gill, Michael (author); Gordon, Scott D (author); Gordon-Smith, Katherine (author); Green, Elaine K (author); Greenwood, Tiffany A (author); Grice, Dorothy E (author); Gross, Magdalena (author); Grozeva, Detelina (author); Guan, Weihua (author); Akil, Huda (author); Gurling, Hugh (author); De Haan, Lieuwe (author); Haines, Jonathan L (author); Hakonarson, Hakon (author); Hallmayer, Joachim (author); Hamilton, Steven P (author); Hamshere, Marian L (author); Hansen, Thomas F (author); Hartmann, Annette M (author); Hautzinger, Martin (author); Amin, Farooq (author); Heath, Andrew C (author); Henders, Anjali K (author); Herms, Stefan (author); Hickie, Ian B (author); Hipolito, Maria (author); Hoefels, Susanne (author); Holmans, Peter A (author); Holsboer, Florian (author); Hoogendijk, Witte J (author); Hottenga, Jouke-Jan (author); Andreassen, Ole A (author); Hultman, Christina M (author); Hus, Vanessa (author); Ingason, Andres (author); Ising, Marcus (author); Jamain, Stephane (author); Jones, Edward G (author); Jones, Ian (author); Jones, Lisa (author); Tzeng, Jung-Ying (author); Kahler, Anna K (author); Anjorin, Adebayo (author); Kahn, Rene S (author); Kandaswamy, Radhika (author); Keller, Matthew C (author); Kennedy, James L (author); Kenny, Elaine (author); Kent, Lindsey (author); Kim, Yunjung (author); Kirov, George K (author); Klauck, Sabine M (author); Klei, Lambertus (author); Anney, Richard (author); Knowles, James A (author); Kohli, Martin A (author); Koller, Daniel L (author); Konte, Bettina (author); Korszun, Ania (author); Krabbendam, Lydia (author); Krasucki, Robert (author); Kuntsi, Jonna (author); Kwan, Phoenix (author); Landen, Mikael (author); Anttila, Verneri (author); Langstrom, Niklas (author); Lathrop, Mark (author); Lawrence, Jacob (author); Lawson, William B (author); Leboyer, Marion (author); Ledbetter, David H (author); Lee, Phil H (author); Lencz, Todd (author); Lesch, Klaus-Peter (author); Levinson, Douglas F (author); Arking, Dan E (author); Lewis, Cathryn M (author); Li, Jun (author); Lichtenstein, Paul (author); Lieberman, Jeffrey A (author); Lin, Dan-Yu (author); Linszen, Don H (author); Liu, Chunyu (author); Lohoff, Falk W (author); Loo, Sandra K (author); Lord, Catherine (author); Asherson, Philip (author); Lowe, Jennifer K (author); Lucae, Susanne (author); MacIntyre, Donald J (author); Madden, Pamela A F (author); Maestrini, Elena (author); Magnusson, Patrik K E (author); Mahon, Pamela B (author); Maier, Wolfgang (author); Malhotra, Anil K (author); Mane, Shrikant M (author); Neale, Benjamin M (author); Azevedo, Maria H (author); Martin, Christa L (author); Martin, Nicholas G (author); Mattheisen, Manuel (author); Matthews, Keith (author); Mattingsdal, Morten (author); McCarroll, Steven A (author); McGhee, Kevin A (author); McGough, James J (author); McGrath, Patrick J (author); McGuffin, Peter (author); Backlund, Lena (author); McInnis, Melvin G (author); McIntosh, Andrew (author); McKinney, Rebecca (author); McLean, Alan W (author); McMahon, Francis J (author); McMahon, William M (author); McQuillin, Andrew (author); Medeiros, Helena (author); Medland, Sarah E (author); Meier, Sandra (author); Badner, Judith A (author); Melle, Ingrid (author); Meng, Fan (author); Meyer, Jobst (author); Middeldorp, Christel M (author); Middleton, Lefkos (author); Milanova, Vihra (author); Miranda, Ana (author); Monaco, Anthony P (author); Montgomery, Grant W (author); Moran, Jennifer L (author); Bailey, Anthony J (author); Moreno-De-Luca, Daniel (author); Morken, Gunnar (author); Morris, Derek W (author); Morrow, Eric M (author); Moskvina, Valentina (author); Muglia, Pierandrea (author); Muhleisen, Thomas W (author); Muir, Walter J (author); Muller-Myhsok, Bertram (author); Murtha, Michael (author); Banaschewski, Tobias (author); Myers, Richard M (author); Myin-Germeys, Inez (author); Neale, Michael C (author); Nelson, Stan F (author); Nievergelt, Caroline M (author); Nikolov, Ivan (author); Nimgaonkar, Vishwajit (author); Nolen, Willem A (author); Nothen, Markus M (author); Nurnberger, John I (author); Barchas, Jack D (author); Nwulia, Evaristus A (author); Nyholt, Dale R (author); O'Dushlaine, Colm (author); Oades, Robert D (author); Olincy, Ann (author); Oliveira, Guiomar (author); Olsen, Line (author); Ophoff, Roel A (author); Osby, Urban (author); Owen, Michael J (author); Barnes, Michael R (author); Palotie, Aarno (author); Parr, Jeremy R (author); Paterson, Andrew D (author); Pato, Carlos N (author); Pato, Michele T (author); Penninx, Brenda W (author); Pergadia, Michele L (author); Pericak-Vance, Margaret A (author); Pickard, Benjamin S (author); Pimm, Jonathan (author); Barrett, Thomas B (author); Piven, Joseph (author); Posthuma, Danielle (author); Potash, James B (author); Poustka, Fritz (author); Propping, Peter (author); Puri, Vinay (author); Quested, Digby J (author); Quinn, Emma M (author); Ramos-Quiroga, Josep Antoni (author); Rasmussen, Henrik B (author); Bass, Nicholas (author); Raychaudhuri, Soumya (author); Rehnstrom, Karola (author); Reif, Andreas (author); Ribases, Marta (author); Rice, John P (author); Rietschel, Marcella (author); Roeder, Kathryn (author); Roeyers, Herbert (author); Rossin, Lizzy (author); Rothenberger, Aribert (author); Battaglia, Agatino (author); Rouleau, Guy (author); Ruderfer, Douglas (author); Rujescu, Dan (author); Sanders, Alan R (author); Sanders, Stephan J (author); Santangelo, Susan L (author); Sergeant, Joseph A (author); Schachar, Russell (author); Schalling, Martin (author); Schatzberg, Alan F (author); Faraone, Stephen V (author); Bauer, Michael (author); Scheftner, William A (author); Schellenberg, Gerard D (author); Scherer, Stephen W (author); Schork, Nicholas J (author); Schulze, Thomas G (author); Schumacher, Johannes (author); Schwarz, Markus (author); Scolnick, Edward (author); Scott, Laura J (author); Shi, Jianxin (author); Bayes, Monica (author); Shilling, Paul D (author); Shyn, Stanley I (author); Silverman, Jeremy M (author); Slager, Susan L (author); Smalley, Susan L (author); Smit, Johannes H (author); Smith, Erin N (author); Sonuga-Barke, Edmund J S (author); St. Clair, David (author); State, Matthew (author); Bellivier, Frank (author); Steffens, Michael (author); Steinhausen, Hans-Christoph (author); Strauss, John S (author); Strohmaier, Jana (author); Stroup, T Scott (author); Sutcliffe, James S (author); Szatmari, Peter (author); Szelinger, Szabocls (author); Thirumalai, Srinivasa (author); Thompson, Robert C (author); Bergen, Sarah E (author); Todorov, Alexandre A (author); Tozzi, Federica (author); Treutlein, Jens (author); Uhr, Manfred (author); van den Oord, Edwin J C G (author); Van Grootheest, Gerard (author); Van Os, Jim (author); Vicente, Astrid M (author); Vieland, Veronica J (author); Vincent, John B (author); Berrettini, Wade (author); Visscher, Peter M (author); Walsh, Christopher A (author); Wassink, Thomas H (author); Watson, Stanley J (author); Weissman, Myrna M (author); Werge, Thomas (author); Wienker, Thomas F (author); Wijsman, Ellen M (author); Willemsen, Gonneke (author); Williams, Nigel (author); Betancur, Catalina (author); Willsey, A Jeremy (author); Witt, Stephanie H (author); Xu, Wei (author); Young, Allan H (author); Yu, Timothy W (author); Zammit, Stanley (author); Zandi, Peter P (author); Zhang, Peng (author); Zitman, Frans G (author); Zollner, Sebastian (author); Bettecken, Thomas (author); Devlin, Bernie (author); Kelsoe, John R (author); Sklar, Pamela (author); Daly, Mark J (author); O'Donovan, Michael C (author); Craddock, Nicholas (author); Sullivan, Patrick F (author); Smoller, Jordan W (author); Kendler, Kenneth S (author); Wray, Naomi R (author); Biederman, Joseph (author); Binder, Elisabeth B (author); Black, Donald W (author); Purcell, Shaun M (author); Blackwood, Douglas H R (author); Bloss, Cinnamon S (author); Boehnke, Michael (author); Boomsma, Dorret I (author); Breen, Gerome (author); Breuer, Rene (author); Bruggeman, Richard (author); Cormican, Paul (author); Buccola, Nancy G (author); Buitelaar, Jan K (author); Perlis, Roy H (author); Bunney, William E (author); Buxbaum, Joseph D (author); Byerley, William F (author); Byrne, Enda M (author); Caesar, Sian (author); Cahn, Wiepke (author); Cantor, Rita M (author); Casas, Miguel (author); Chakravarti, Aravinda (author); Chambert, Kimberly (author); Mowry, Bryan J (author); Choudhury, Khalid (author); Cichon, Sven (author); Cloninger, C Robert (author); Collier, David A (author); Cook, Edwin H (author); Coon, Hilary (author); Cormand, Bru (author); Corvin, Aiden (author); Coryell, William H (author); Craig, David W (author); Thapar, Anita (author); Craig, Ian W (author); Crosbie, Jennifer (author); Cuccaro, Michael L (author); Curtis, David (author); Czamara, Darina (author); Datta, Susmita (author); Dawson, Geraldine (author); Day, Richard (author); De Geus, Eco J (author); Degenhardt, Franziska (author); Goddard, Michael E (author); Djurovic, Srdjan (author); Donohoe, Gary J (author); Doyle, Alysa E (author); Duan, Jubao (author); Dudbridge, Frank (author); Duketis, Eftichia (author); Ebstein, Richard P (author); Edenberg, Howard J (author); Elia, Josephine (author); Ennis, Sean (author); Witte, John S (author); Etain, Bruno (author); Fanous, Ayman (author); Farmer, Anne E (author); Ferrier, I Nicol (author); Flickinger, Matthew (author); Fombonne, Eric (author); Foroud, Tatiana (author); Frank, Josef (author); Franke, Barbara (author); Fraser, Christine (author)
Publication Date: 2013
Open Access: Yes
DOI: 10.1038/ng.2711Open Access Link
Handle Link: https://hdl.handle.net/1959.11/22066
Open Access Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800159Open Access Link
Abstract: Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.c.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Publication Type: Journal Article
Source of Publication: Nature Genetics, 45(9), p. 984-994
Publisher: Nature Publishing Group
Place of Publication: United States of America
ISSN: 1061-4036
1546-1718
Field of Research (FOR): 060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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