Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor

Title
Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor
Publication Date
2012
Author(s)
Keller, Matthew C
Simonson, Matthew A
Ripke, Stephan
Neale, Ben M
Gejman, Pablo V
Howrigan, Daniel P
Lee, Sang Hong
Lencz, Todd
Levinson, Douglas F
Sullivan, Patrick F
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Public Library of Science
Place of publication
United States of America
DOI
10.1371/journal.pgen.1002656
UNE publication id
une:22236
Abstract
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by ∼17% for every 1% increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time.
Link
Citation
PLoS Genetics, 8(4), p. 1-11
ISSN
1553-7404
1553-7390
Start page
1
End page
11

Files:

NameSizeformatDescriptionLink