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Title: Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Contributor(s): Lee, Sang Hong  (author); DeCandia, Teresa R (author); Visscher, Peter M (author); Wray, Naomi R (author); Ripke, Stephan (author); Yang, Jian (author); Sullivan, Patrick F (author); Goddard, Michael E (author); Keller, Matthew C (author)
Corporate Author: The International Schizophrenia Consortium (ISC)
The Molecular Genetics of Schizophrenia Collaboration (MGS)
The Schizophrenia Psychiatric Genome Wide Association Study Consortium (PGC-SCZ)
Publication Date: 2012
Open Access: Yes
DOI: 10.1038/ng.1108Open Access Link
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Abstract: Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 x 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 x 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
Publication Type: Journal Article
Source of Publication: Nature Genetics, 44(3), p. 247-250
Publisher: Nature Publishing Group
Place of Publication: United States of America
ISSN: 1061-4036
Field of Research (FOR): 060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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