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Title: The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: A systematic review and meta-analysis
Contributor(s): Ostman, Cecilia (author); Smart, Neil  (author)orcid ; Morcos, D (author); Duller, A (author); Ridley, W (author); Jewiss, Daniel (author)
Publication Date: 2017
Open Access: Yes
DOI: 10.1186/s12933-017-0590-yOpen Access Link
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Abstract: Background: Purpose: to establish if exercise training improves clinical outcomes in people with metabolic syndrome (MetS). Registered with PROSPERO international prospective register of systematic reviews (https://www.crd.york. Data sources: studies were identified through a MEDLINE search strategy (1985 to Jan 12, 2017), Cochrane controlled trials registry, CINAHL and SPORTDiscus. Study selection: prospective randomized or controlled trials of exercise training in humans with metabolic syndrome, lasting 12 weeks or more. Results: We included 16 studies with 23 intervention groups; 77,000 patient-hours of exercise training. In analyses of aerobic exercise studies versus control: body mass index was significantly reduced, mean difference (MD) −0.29 (kg m⁻²) (95% CI −0.44, −0.15, p < 0.0001); body mass was significantly reduced, MD −1.16 kg (95% CI −1.83, −0.48, p = 0.0008); waist circumference was significantly reduced MD −1.37 cm (95% CI −2.02, −0.71, p < 0.0001), peak VO₂ was significantly improved MD 3.00 mL kg⁻¹ min⁻¹ (95% CI 1.92, 4.08, p < 0.000001); systolic blood pressure and diastolic blood pressure were significantly reduced, MD −2.54 mmHg (95% CI −4.34, −0.75, p = 0.006), and, MD −2.27 mmHg (95% CI −3.47, −1.06, p = 0.0002) respectively; fasting blood glucose was significantly reduced MD −0.16 mmol L−¹ (95% CI −0.32, −0.01, p = 0.04); triglycerides were significantly reduced MD −0.21 mmol L⁻¹ (95% CI −0.29, −0.13, p < 0.00001); and low density lipoprotein was significantly reduced MD −0.03 mmol L⁻¹ (95% CI −0.05, −0.00, p = 0.02). In analyses of combined exercise versus control: waist circumference, MD −3.80 cm (95% CI −5.65, −1.95, p < 0.0001); peak VO₂ MD 4.64 mL kg⁻¹ min⁻¹ (95% CI 2.42, 6.87, p < 0.0001); systolic blood pressure MD −3.79 mmHg (95% CI −6.18, −1.40, p = 0.002); and high density lipoprotein (HDL) MD 0.14 (95% CI 0.04, 0.25, p = 0.009) were all significantly improved. We found no significant differences between outcome measures between the two exercise interventions. Conclusions: Exercise training improves body composition, cardiovascular, and, metabolic outcomes in people with metabolic syndrome. For some outcome measures, isolated aerobic exercise appears optimal.
Publication Type: Journal Article
Source of Publication: Cardiovascular Diabetology, v.16, p. 1-11
Publisher: BioMed Central Ltd
Place of Publication: United Kindgom
ISSN: 1475-2840
Field of Research (FOR): 110602 Exercise Physiology
110107 Metabolic Medicine
110306 Endocrinology
Socio-Economic Outcome Codes: 920103 Cardiovascular System and Diseases
920205 Health Education and Promotion
920106 Endocrine Organs and Diseases (excl. Diabetes)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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