Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/21337
Title: Preliminary evidence of age-dependent clinical signs associated with porcine circovirus 2b in experimentally infected CH3/Rockefeller mice
Contributor(s): de Castro, Alessandra M M G (author); Cruz, Tais F (author); Richtzenhain, Leonardo J (author); Yamada, Katarina B (author); Gerber, Priscilla Freitas  (author)orcid ; Gabardo, Michelle P (author); Araujo Jr, Joao P (author); Guedes, Roberto M C (author); Mori, Cinthia K (author); Oliveira, Camila P (author); Santos, Sueli S (author)
Publication Date: 2015
DOI: 10.1016/j.rvsc.2015.09.008
Handle Link: https://hdl.handle.net/1959.11/21337
Abstract: Mice and rats are susceptible to porcine circovirus 2b (PCV2) infection under field and experimental conditions. However, whether PCV2 induces disease in rodents remains a matter of debate. The objectives of the present study were to determine whether PCV2-induced disease in mice is age-dependent and whether intranasally inoculated animals are able to infect animals they come into contact with. Twenty-five CH3/Rockefeller mice were divided into six groups and intranasally inoculated with 25 µL of either PCV2b or PBS on days 0, 3 and 6. One group remained untreated. Two age groups were tested: 3-week-old mice and 6-week-old mice. The administration of three PCV2 intranasal inoculations at intervals of three days was able to induce infection and support virus transmission in susceptible mice, regardless of the age at inoculation. The clinical signs associated with PCV2 infection were more severe in younger mice, and PCV2-DNA load was higher in their faeces. In conclusion, PCV2 induced disease in mice.
Publication Type: Journal Article
Source of Publication: Research in Veterinary Science, v.103, p. 70-72
Publisher: Elsevier Ltd
Place of Publication: United Kingdom
ISSN: 1532-2661
0034-5288
Fields of Research (FoR) 2008: 070706 Veterinary Medicine
070705 Veterinary Immunology
070712 Veterinary Virology
Fields of Research (FoR) 2020: 300907 Veterinary medicine (excl. urology)
300906 Veterinary immunology
300914 Veterinary virology
Socio-Economic Objective (SEO) 2008: 830308 Pigs
Socio-Economic Objective (SEO) 2020: 100410 Pigs
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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