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https://hdl.handle.net/1959.11/21333
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Crawford, Kimberly | en |
dc.contributor.author | Lager, Kelly | en |
dc.contributor.author | Miller, Laura | en |
dc.contributor.author | Opriessnig, Tanja | en |
dc.contributor.author | Gerber, Priscilla Freitas | en |
dc.contributor.author | Hesse, Richard | en |
dc.date.accessioned | 2017-06-08T16:28:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Veterinary Research, v.46, p. 1-9 | en |
dc.identifier.issn | 1297-9716 | en |
dc.identifier.issn | 0928-4249 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/21333 | - |
dc.description.abstract | Clinical disease associated with porcine epidemic diarrhea virus (PEDV) infection in naïve pigs is well chronicled; however, information on endemic PEDV infection is limited. To characterize chronic PEDV infection, the duration of infectious virus shedding and development of protective immunity was determined. On Day 0 (D0), a growing pig was challenged with PEDV and 13 contacts were commingled. On D7, 9 contact pigs (principal virus group (PG)), were selected, moved to a separate room and commingled with one sentinel pig (S1). This process was repeated weekly with S2, S3 and S4. The PG was PEDV-positive by PCR from D3-11, with some pigs intermittently positive to D42. Pigs S1 and S2 were PEDV-positive within 24 hours of commingling. Antibodies were detected in all PG by D21 and by 7 days post-contact in S1 and S2. Pigs S3 and S4 were PCR and antibody negative following commingling. To evaluate protective immunity, 5 naïve pigs (N) and the PG were challenged (N/C, PG/C) with homologous virus on D49. All N/C pigs were PEDV PCR-positive by D52 with detection out to D62 in 3/5 N/C pigs. All PG/C pigs were PEDV PCR-negative post-challenge. By D63, all N/C seroconverted. Although PEDV RNA was demonstrated in pigs after primary infection until D42, infectious PEDV capable of horizontal transmission to naïve pigs was only shed 14-16 days after infection to age-matched pigs. Homologous re-challenge 49 days post initial PEDV exposure did not result in re-infection of the pigs. This demonstrates potential for an effective PEDV vaccine. | en |
dc.language | en | en |
dc.publisher | BioMed Central Ltd | en |
dc.relation.ispartof | Veterinary Research | en |
dc.title | Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1186/s13567-015-0180-5 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Veterinary Virology | en |
dc.subject.keywords | Veterinary Immunology | en |
local.contributor.firstname | Kimberly | en |
local.contributor.firstname | Kelly | en |
local.contributor.firstname | Laura | en |
local.contributor.firstname | Tanja | en |
local.contributor.firstname | Priscilla Freitas | en |
local.contributor.firstname | Richard | en |
local.subject.for2008 | 070712 Veterinary Virology | en |
local.subject.for2008 | 070705 Veterinary Immunology | en |
local.subject.seo2008 | 830308 Pigs | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.email | pgerber2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-chute-20170602-153738 | en |
local.publisher.place | United Kingdom | en |
local.identifier.runningnumber | 49 | en |
local.format.startpage | 1 | en |
local.format.endpage | 9 | en |
local.identifier.scopusid | 84928715441 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 46 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Crawford | en |
local.contributor.lastname | Lager | en |
local.contributor.lastname | Miller | en |
local.contributor.lastname | Opriessnig | en |
local.contributor.lastname | Gerber | en |
local.contributor.lastname | Hesse | en |
dc.identifier.staff | une-id:pgerber2 | en |
local.profile.orcid | 0000-0002-8343-8299 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:21526 | en |
local.identifier.handle | https://hdl.handle.net/1959.11/21333 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Crawford, Kimberly | en |
local.search.author | Lager, Kelly | en |
local.search.author | Miller, Laura | en |
local.search.author | Opriessnig, Tanja | en |
local.search.author | Gerber, Priscilla Freitas | en |
local.search.author | Hesse, Richard | en |
local.uneassociation | Unknown | en |
local.year.published | 2015 | en |
local.subject.for2020 | 300914 Veterinary virology | en |
local.subject.for2020 | 300906 Veterinary immunology | en |
local.subject.seo2020 | 100410 Pigs | en |
Appears in Collections: | Journal Article |
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