Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/21266
Title: | A commercial vaccine based on PCV2a and an experimental vaccine based on a variant mPCV2b are both effective in protecting pigs against challenge with a 2013 U.S. variant mPCV2b strain | Contributor(s): | Opriessnig, Tanja (author); Gerber, Priscilla Freitas (author) ; Xiao, Chao-Ting (author); Mogler, Mark (author); Halbur, Patrick G (author) | Publication Date: | 2014 | DOI: | 10.1016/j.vaccine.2013.11.010 | Handle Link: | https://hdl.handle.net/1959.11/21266 | Abstract: | During 2012 and 2013, an apparent increase in porcine circovirus associated disease occurred in the USA. A variant PCV2b strain designated mPCV2b was recovered from many of these cases. This raised concerns of a decrease in efficacy of commercially available PCV2 vaccines. The objective of this study was to compare the ability of a commercial PCV2a-based vaccine and an experimental mPCV2b-based vaccine to control mPCV2b-associated disease, lesions, and viremia in a challenge model. Twenty-six caesarian-derived, colostrum-deprived pigs were randomly assigned to one of four groups: (1) vaccinated with a commercial PCV2a-based vaccine and challenged (PCV2a-VAC; n= 7), (2) vaccinated with an experimental mPCV2b-based vaccine and challenged (mPCV2b; n= 7), (3) sham-vaccinated with saline and challenged (positive controls; n= 7), and (4) sham-vaccinated with saline without challenge (negative controls; n= 5). Vaccination was done on D0 and D14, challenge was done on D28 using a tissue homogenate containing PRRSV and mPCV2b and the experiment was terminated on D49. Among the challenged pigs, 47.6% (10/21) developed severe clinical disease and either died or had to be humanely euthanized between D39 and D48 (11-20 days after challenge). PCV2 viremia was almost completely absent in the vaccinated groups regardless of vaccine type except for two PCV2a-vaccinated pigs which had detectable PCV2 DNA levels on individual days after challenge. Microscopic lesions typical of PCV2 infection were limited to the positive control group which developed mild-to-severe lesions associated with low-to-abundant PCV2 antigen. Under the conditions of this study, PCV2 vaccines regardless of PCV2 type were effective against mPCV2b challenge. | Publication Type: | Journal Article | Source of Publication: | Vaccine, 32(2), p. 230-237 | Publisher: | Elsevier Ltd | Place of Publication: | United Kingdom | ISSN: | 1873-2518 0264-410X |
Fields of Research (FoR) 2008: | 070712 Veterinary Virology 070706 Veterinary Medicine 070705 Veterinary Immunology |
Fields of Research (FoR) 2020: | 300914 Veterinary virology 300907 Veterinary medicine (excl. urology) 300906 Veterinary immunology |
Socio-Economic Objective (SEO) 2008: | 830308 Pigs | Socio-Economic Objective (SEO) 2020: | 100410 Pigs | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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