Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/21096
Title: Leptin pharmacokinetics in male mice
Contributor(s): Hart, Robert A  (author)orcid ; Dobos, Robin C  (author)orcid ; Agnew, Linda L  (author)orcid ; Smart, Neil A  (author)orcid ; McFarlane, James R  (author)orcid 
Publication Date: 2017
Open Access: Yes
DOI: 10.1530/ec-16-0089Open Access Link
Handle Link: https://hdl.handle.net/1959.11/21096
Abstract: Pharmacokinetics of leptin in mammals has not been studied in detail and only one study has examined more than one time point in non-mutant mice and this was in a female mice. This is the first study to describe leptin distribution over a detailed time course in normal male mice. A physiologic dose (12 ng) of radiolabelled leptin was injected into adult male mice via the lateral tail vein and tissues were dissected out and measured for radioactivity over a time course of up to two hours. Major targets were the digestive tract, kidneys, skin and lungs. The brain was not a major target, and 0.15% of the total dose was recovered from the brain 5 min after administration. Major differences appear to exist in the distribution of leptin between the male and female mice, indicating a high degree of sexual dimorphism. Although the half-lives were similar between male and female mice, almost twice the proportion of leptin was recovered from the digestive tract of male mice in comparison to that reported previously for females. This would seem to indicate a major difference in leptin distribution and possibly function between males and females.
Publication Type: Journal Article
Source of Publication: Endocrine Connections, 6(1), p. 20-26
Publisher: BioScientifica Ltd
Place of Publication: United Kingdom
ISSN: 2049-3614
Fields of Research (FoR) 2008: 119999 Medical and Health Sciences not elsewhere classified
111501 Basic Pharmacology
060699 Physiology not elsewhere classified
Fields of Research (FoR) 2020: 320803 Systems physiology
Socio-Economic Objective (SEO) 2008: 970106 Expanding Knowledge in the Biological Sciences
929999 Health not elsewhere classified
920106 Endocrine Organs and Diseases (excl. Diabetes)
Socio-Economic Objective (SEO) 2020: 280102 Expanding knowledge in the biological sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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