Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/21093
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Sang Hongen
dc.contributor.authorWeerasinghe, Shalaneeen
dc.contributor.authorWray, Naomi Ren
dc.contributor.authorGoddard, Michael Een
dc.contributor.authorVan Der Werf, Julius Hen
dc.date.accessioned2017-05-25T18:17:00Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports, v.7, p. 1-13en
dc.identifier.issn2045-2322en
dc.identifier.urihttps://hdl.handle.net/1959.11/21093-
dc.description.abstractGenomic prediction shows promise for personalised medicine in which diagnosis and treatment are tailored to individuals based on their genetic profiles for complex diseases. We present a theoretical framework to demonstrate that prediction accuracy can be improved by targeting more informative individuals in the data set used to generate the predictors ("discovery sample") to include those with genetically close relationships with the subjects put forward for risk prediction. Increase of prediction accuracy from closer relationships is achieved under an additive model and does not rely on any family or interaction effects. Using theory, simulations and real data analyses, we show that the predictive accuracy or the area under the receiver operating characteristic curve (AUC) increased exponentially with decreasing effective size (Nₑ), i.e. when individuals are closely related. For example, with the sample size of discovery set N = 3000, heritability h² = 0.5 and population prevalence K = 0.1, AUC value approached to 0.9 and the top percentile of the estimated genetic profile scores had 23 times higher proportion of cases than the general population. This suggests that there is considerable room to increase prediction accuracy by using a design that does not exclude closer relationships.en
dc.languageenen
dc.publisherNature Publishing Groupen
dc.relation.ispartofScientific Reportsen
dc.titleUsing information of relatives in genomic prediction to apply effective stratified medicineen
dc.typeJournal Articleen
dc.identifier.doi10.1038/srep42091en
dcterms.accessRightsGolden
dc.subject.keywordsAnimal Breedingen
local.contributor.firstnameSang Hongen
local.contributor.firstnameShalaneeen
local.contributor.firstnameNaomi Ren
local.contributor.firstnameMichael Een
local.contributor.firstnameJulius Hen
local.subject.for2008070201 Animal Breedingen
local.subject.seo2008830311 Sheep - Woolen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of E&RS - Animal Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailslee38@une.edu.auen
local.profile.emailsweerasi@une.edu.auen
local.profile.emailjvanderw@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170330-094621en
local.publisher.placeUnited Kingdomen
local.identifier.runningnumber42091en
local.format.startpage1en
local.format.endpage13en
local.identifier.scopusid85012098079en
local.peerreviewedYesen
local.identifier.volume7en
local.access.fulltextYesen
local.contributor.lastnameLeeen
local.contributor.lastnameWeerasingheen
local.contributor.lastnameWrayen
local.contributor.lastnameGoddarden
local.contributor.lastnameVan Der Werfen
dc.identifier.staffune-id:slee38en
dc.identifier.staffune-id:sweerasien
dc.identifier.staffune-id:jvanderwen
local.profile.orcid0000-0003-2512-1696en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:21286en
local.identifier.handlehttps://hdl.handle.net/1959.11/21093en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleUsing information of relatives in genomic prediction to apply effective stratified medicineen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorLee, Sang Hongen
local.search.authorWeerasinghe, Shalaneeen
local.search.authorWray, Naomi Ren
local.search.authorGoddard, Michael Een
local.search.authorVan Der Werf, Julius Hen
local.uneassociationUnknownen
local.identifier.wosid000393694000001en
local.year.published2017en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/9666aeab-be49-41e6-ae1a-a74e9d211221en
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.seo2020100413 Sheep for woolen
Appears in Collections:Journal Article
Files in This Item:
2 files
File Description SizeFormat 
Show simple item record

SCOPUSTM   
Citations

32
checked on Mar 9, 2024

Page view(s)

1,090
checked on Apr 2, 2023

Download(s)

2
checked on Apr 2, 2023
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.