Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20990
Title: Effect of exercise on diastolic function in heart failure patients: a systematic review and meta-analysis
Contributor(s): Pearson, M J  (author)orcid ; Mungovan, S F (author); Smart, Neil  (author)orcid 
Publication Date: 2017
DOI: 10.1007/s10741-017-9600-0
Handle Link: https://hdl.handle.net/1959.11/20990
Abstract: Diastolic dysfunction contributes to the development and progression of heart failure. Conventional echocardiography and tissue Doppler imaging are widely utilised in clinical research providing a number of indices of diastolic function valuable in the diagnosis and prognosis of heart failure patients. The aim of this meta-analysis was to quantify the effect of exercise training on diastolic function in patients with heart failure. Exercise training studies that investigate different indices of diastolic function in patients with heart failure have reported that exercise training improves diastolic function in these patients. We sought to add to the current literature by quantifying, where possible, the effect of exercise training on diastolic function. We conducted database searches (PubMed, EBSCO, EMBASE, and Cochrane Trials Register to 31 July 2016) for exercise based rehabilitation trials in heart failure, using the search terms 'exercise training, diastolic function and diastolic dysfunction'. Data from six studies, with a total of 266 heart failure with reduced ejection fraction (HFrEF) participants, 144 in intervention groups and 122 in control groups, indicated a significant reduction in the ratio of early diastolic transmitral velocity (E) to early diastolic tissue velocity (E') (E/E' ratio) with exercise training, exercise vs. control mean difference (MD) of -2.85 (95% CI -3.66 to -2.04, p < 0.00001). Data from five studies in heart failure with preserved ejection fraction (HFpEF) patients, with a total of 204 participants, 115 in intervention groups and 89 in control groups, also demonstrated a significant improvement in E/E' in exercise vs. control MD of -2.38 (95% CI -3.47 to -1.28, p < 0.0001).
Publication Type: Journal Article
Source of Publication: Heart Failure Reviews, 22(2), p. 229-242
Publisher: Springer New York LLC
Place of Publication: United States of America
ISSN: 1573-7322
1382-4147
Fields of Research (FoR) 2008: 110602 Exercise Physiology
110201 Cardiology (incl. Cardiovascular Diseases)
Fields of Research (FoR) 2020: 420702 Exercise physiology
320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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