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Title: Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis
Contributor(s): Grace, Aimee  (author); Chan Erick, (author); Giallauria, Francesco  (author); Graham, Petra L (author); Smart, Neil  (author)orcid 
Publication Date: 2017
Open Access: Yes
DOI: 10.1186/s12933-017-0518-6Open Access Link
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Abstract: Aims: To establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes. Methods: A systematic search was conducted to identify studies through a search of MEDLINE (1985 to Sept 1, 2016, Cochrane Controlled Trials Registry (1966 to Sept 1, 2016), CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of MeSH and free text terms for related key concepts. Searches were limited to prospective randomized or controlled trials of aerobic exercise training in humans with type II diabetes, aged >18 years, lasting >2 weeks. Results: Our analysis included 27 studies (38 intervention groups) totalling 1372 participants, 737 exercise and 635 from control groups. The studies contain data from 39,435 patient-hours of exercise training. Our analyses showed improvements with exercise in glycosylated haemoglobin (HbA1C%) MD: -0.71%, 95% CI -1.11, -0.31; p value = 0.0005. There were significant moderator effects; for every additional week of exercise HbA1C% reduces between 0.009 and 0.04%, p = 0.002. For those exercising at vigorous intensity peak oxygen consumption (peak VO2) increased a further 0.64 and 5.98 ml/kg/min compared to those doing low or moderate intensity activity. Homeostatic model assessment of insulin resistance (HOMA-IR) was also improved with exercise MD: -1.02, 95% CI -1.77, -0.28; p value = 0.007; as was fasting serum glucose MD: -12.53 mmol/l, 95% CI -18.94, -6.23; p value <0.0001; and serum MD: -10.39 IU, 95% CI -17.25, -3.53; p value = 0.003. Conclusions: Our analysis support existing guidelines that for those who can tolerate it, exercise at higher intensity may offer superior fitness benefits and longer program duration will optimize reductions in HbA1C%.
Publication Type: Journal Article
Source of Publication: Cardiovascular Diabetology, v.16, p. 1-10
Publisher: BioMed Central Ltd
Place of Publication: United Kingdom
ISSN: 1475-2840
Field of Research (FOR): 110499 Complementary and Alternative Medicine not elsewhere classified
110201 Cardiology (incl. Cardiovascular Diseases)
Socio-Economic Outcome Codes: 920103 Cardiovascular System and Diseases
920106 Endocrine Organs and Diseases (excl. Diabetes)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
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