Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20949
Title: In silico exploration of the mechanisms that underlie parasite-induced anorexia in sheep
Contributor(s): Laurenson, Yan  (author); Bishop, Stephen C (author); Kyriazakis, Ilias (author)
Publication Date: 2011
Open Access: Yes
DOI: 10.1017/s0007114511001371Open Access Link
Handle Link: https://hdl.handle.net/1959.11/20949
Abstract: A model was used to investigate two mechanisms describing reductions in food intake (anorexia) observed during gastrointestinal parasitism in lambs, and to explore relationships between anorexia and food composition. The mechanisms were either a reduction in intrinsic growth rate, leading to a consequent reduction in food intake (mechanism 1; M1), or a direct reduction in food intake (mechanism 2; M2). For both mechanisms, lambs growing from 2 to 6 months of age were modelled, with one of three levels of trickle challenge with 'Teladorsagia circumcincta'. Scenarios were simulated for feeds varying in either protein or energy content, or both. Major differences were found between the predictions resulting from M1 and M2 on low-energy foods that constrained the intake of uninfected lambs through bulk. With M1, food intake was governed by the first operating constraint, whereas with M2 an additivity of constraints was observed. On the other foods, the duration of anorexia increased with increasing energy content of feed for M1, whilst the duration of anorexia decreased with increasing protein content of feed for M2. For foods that did not have an impact upon lambs' gastrointestinal tract capacity, published data were consistent with predictions of M2. Due to an absence of experimental data, no conclusions could be drawn for relationships between anorexia and food composition in the presence of other limiting constraints, such as bulk for low-energy foods. In conclusion, available experimental data and model predictions were consistent with anorexia having an impact directly on food intake, and with impacts of anorexia increasing with decreasing protein content.
Publication Type: Journal Article
Source of Publication: British Journal of Nutrition, 106(7), p. 1023-1039
Publisher: Cambridge University Press
Place of Publication: United Kingdom
ISSN: 1475-2662
0007-1145
Field of Research (FOR): 070708 Veterinary Parasitology
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Environmental and Rural Science

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