Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20845
Title: Can the sensitivity of the histopathological diagnosis of coeliac disease be increased and can treatment progression be monitored using mathematical modelling of histological sections? - A pilot study
Contributor(s): Charlesworth, Richard P G  (author)orcid ; Andronicos, Nicholas M  (author)orcid ; Scott, David R (author); McFarlane, James R  (author)orcid ; Agnew, Linda L  (author)orcid 
Publication Date: 2017
DOI: 10.1016/j.advms.2016.06.002
Handle Link: https://hdl.handle.net/1959.11/20845
Abstract: Purpose: The aim of this pilot study was to attempt to define a set of equations from histological observations of tissue affected with coeliac disease (CD) to predict Marsh score. Material/methods: Tissue from 15 patients with untreated CD, 6 patients with treated CD and 9 healthy control patients were stained using the standard H&E, Giemsa's staining for tissue sections and Alcian Blue protocols. A number of histological measures were then taken from each section and the data was used to ultimately design a set of linear predictive algorithms to calculate Marsh score. Results: Using MANOVA and discriminant analysis, two linear functions were defined which could accurately predict the Marsh score of patients 62.5% (full Marsh score) to 79.2% (simplified Marsh score) of the time. Conclusions: This pilot study has shown that a set of objective histological measures can be used to define algorithms to predict Marsh score in CD patients and also monitor treatment compliance and progression.
Publication Type: Journal Article
Source of Publication: Advances in Medical Sciences, 62(1), p. 136-142
Publisher: Elsevier Urban & Partner Sp
Place of Publication: Poland
ISSN: 1898-4002
1896-1126
Fields of Research (FoR) 2008: 110703 Autoimmunity
Fields of Research (FoR) 2020: 320803 Systems physiology
Socio-Economic Objective (SEO) 2008: 920108 Immune System and Allergy
Socio-Economic Objective (SEO) 2020: 200104 Prevention of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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