The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

2016

Mallick, Swapan

Li, Heng

Skoglund, Pontus

Lazaridis, Iosif

Sankararaman, Sriram

Fu, Qiaomei

Rohland, Nadin

Renaud, Gabriel

Erlich, Yaniv

Willems, Thomas

Gallo, Carla

Spence, Jeffrey P

Lipson, Mark

Song, Yun S

Poletti, Giovanni

Balloux, Francois

van Driem, George

de Knijff, Peter

Romero, Irene Gallego

Jha, Aashish R

Behar, Doron M

Bravi, Claudio M

Capelli, Cristian

Mathieson, Iain

Hervig, Tor

Moreno-Estrada, Andres

Posukh, Olga L

Balanovska, Elena

Balanovsky, Oleg

Karachanak-Yankova, Sena

Sahakyan, Hovhannes

Toncheva, Draga

Yepiskoposyan, Levon

Tyler-Smith, Chris

Gymrek, Melissa

Xue, Yali

Abdullah, M Syafiq

Ruiz-Linares, Andres

Beall, Cynthia M

Di Rienzo, Anna

Jeong, Choongwon

Starikovskaya, Elena B

Metspalu, Ene

Parik, Juri

Villems, Richard

Racimo, Fernando

Henn, Brenna M

Hodoglugil, Ugur

Mahley, Robert

Sajantila, Antti

Stamatoyannopoulos, George

Wee, Joseph T S

Khusainova, Rita

Khusnutdinova, Elza

Litvinov, Sergey

Ayodo, George

Zhao, Mengyao

Comas, David

Hammer, Michael F

Kivisild, Toomas

Klitz, William

Winkler, Cheryl A

Labuda, Damian

Bamshad, Michael

Jorde, Lynn B

Tishkoff, Sarah A

Watkins, W Scott

Chennagiri, Niru

Metspalu, Mait

Dryomov, Stanislav

Sukernik, Rem

Singh, Lalji

Thangaraj, Kumarasamy

Paabo, Svante

Kelso, Janet

Patterson, Nick

Reich, David

Nordenfelt, Susanne

Tandon, Arti

Journal Article

en

Publication

Nature Publishing Group

United Kingdom

10.1038/nature18964

une:20950

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non- Africans.

link

Nature, 538(7624), p. 201-206

1476-4687

0028-0836

201

206