Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20676
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dc.contributor.authorHsieh, Yves S Yen
dc.contributor.authorWijeyewickrema, Lakshmi Cen
dc.contributor.authorWilkinson, Brendanen
dc.contributor.authorPike, Robert Nen
dc.contributor.authorPayne, Richard Jen
dc.date.accessioned2017-05-05T15:37:00Z
dc.date.issued2014en
dc.identifier.citationAngewandte Chemie (International Edition), 53(15), p. 3947-3951en
dc.identifier.issn1521-3773en
dc.identifier.issn1433-7851en
dc.identifier.urihttps://hdl.handle.net/1959.11/20676en
dc.description.abstractHirudin P6 is a leech-derived anti-thrombotic protein which possesses two post-translational modifications, O-glycosylation and tyrosine sulfation. In this study we report the ligation-based synthesis of a library of hirudin P6 proteins possessing homogeneous glycosylation and sulfation modifications. The nature of the modifications incorporated was shown to have a drastic effect on inhibition against both the fibrinogenolytic and amidolytic activities of thrombin and thus highlights a potential means for attenuating the biological activity of the protein.en
dc.languageenen
dc.publisherWiley-VCH Verlag GmbH & Co KGaAen
dc.relation.ispartofAngewandte Chemie (International Edition)en
dc.titleTotal Synthesis of Homogeneous Variants of Hirudin P6: A Post-Translationally Modified Anti-Thrombotic Leech-Derived Proteinen
dc.typeJournal Articleen
dc.identifier.doi10.1002/anie.201310777en
dc.subject.keywordsBiologically Active Moleculesen
dc.subject.keywordsOrganic Chemical Synthesisen
dc.subject.keywordsProteins and Peptidesen
local.contributor.firstnameYves S Yen
local.contributor.firstnameLakshmi Cen
local.contributor.firstnameBrendanen
local.contributor.firstnameRobert Nen
local.contributor.firstnameRichard Jen
local.subject.for2008030401 Biologically Active Moleculesen
local.subject.for2008030406 Proteins and Peptidesen
local.subject.for2008030503 Organic Chemical Synthesisen
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.subject.seo2008929999 Health not elsewhere classifieden
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailbwilkin7@une.edu.auen
local.profile.emailrichard.payne@sydney.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170323-113111en
local.publisher.placeGermanyen
local.format.startpage3947en
local.format.endpage3951en
local.peerreviewedYesen
local.identifier.volume53en
local.identifier.issue15en
local.title.subtitleA Post-Translationally Modified Anti-Thrombotic Leech-Derived Proteinen
local.contributor.lastnameHsiehen
local.contributor.lastnameWijeyewickremaen
local.contributor.lastnameWilkinsonen
local.contributor.lastnamePikeen
local.contributor.lastnamePayneen
dc.identifier.staffune-id:bwilkin7en
local.profile.orcid0000-0003-1866-6540en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20869en
dc.identifier.academiclevelAcademicen
local.title.maintitleTotal Synthesis of Homogeneous Variants of Hirudin P6en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 26<br />Views: 143<br />Downloads: 0en
local.search.authorHsieh, Yves S Yen
local.search.authorWijeyewickrema, Lakshmi Cen
local.search.authorWilkinson, Brendanen
local.search.authorPike, Robert Nen
local.search.authorPayne, Richard Jen
local.uneassociationUnknownen
local.year.published2014en
local.subject.for2020340401 Biologically active moleculesen
local.subject.for2020340407 Proteins and peptidesen
local.subject.for2020340503 Organic chemical synthesis en
local.subject.seo2020280105 Expanding knowledge in the chemical sciencesen
local.subject.seo2020undefineden
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
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School of Science and Technology
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