Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20378
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dc.contributor.authorBerk, Zoeen
dc.contributor.authorLaurenson, Yanen
dc.contributor.authorForbes, Andrew Ben
dc.contributor.authorKyriazakis, Iliasen
dc.date.accessioned2017-04-10T16:56:00Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal for Parasitology: Drugs and Drug Resistance, 6(3), p. 258-271en
dc.identifier.issn2211-3207en
dc.identifier.urihttps://hdl.handle.net/1959.11/20378-
dc.description.abstractThe development of anthelmintic resistance by helminths can be slowed by maintaining refugia on pasture or in untreated hosts. Targeted selective treatments (TST) may achieve this through the treatment only of individuals that would benefit most from anthelmintic, according to certain criteria. However TST consequences on cattle are uncertain, mainly due to difficulties of comparison between alternative strategies. We developed a mathematical model to compare: 1) the most 'beneficial' indicator for treatment selection and 2) the method of selection of calves exposed to Ostertagia ostertagi, i.e. treating a fixed percentage of the population with the lowest (or highest) indicator values versus treating individuals who exceed (or are below) a given indicator threshold. The indicators evaluated were average daily gain (ADG), faecal egg counts (FEC), plasma pepsinogen, combined FEC and plasma pepsinogen, versus random selection of individuals. Treatment success was assessed in terms of benefit per R (BPR), the ratio of average benefit in weight gain to change in frequency of resistance alleles R (relative to an untreated population). The optimal indicator in terms of BPR for fixed percentages of calves treated was plasma pepsinogen and the worst ADG; in the latter case treatment was applied to some individuals who were not in need of treatment. The reverse was found when calves were treated according to threshold criteria, with ADG being the best target indicator for treatment. This was also the most beneficial strategy overall, with a significantly higher BPR value than any other strategy, but its degree of success depended on the chosen threshold of the indicator. The study shows strong support for TST, with all strategies showing improvements on calves treated selectively, compared with whole-herd treatment at 3, 8, 13 weeks post-turnout. The developed model appeared capable of assessing the consequences of other TST strategies on calf populations.en
dc.languageenen
dc.publisherElsevier Ltden
dc.relation.ispartofInternational Journal for Parasitology: Drugs and Drug Resistanceen
dc.titleModelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calvesen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.ijpddr.2016.11.002en
dcterms.accessRightsGolden
dc.subject.keywordsVeterinary Parasitologyen
dc.subject.keywordsAgricultural Production Systems Simulationen
dc.subject.keywordsAnimal Growth and Developmenten
local.contributor.firstnameZoeen
local.contributor.firstnameYanen
local.contributor.firstnameAndrew Ben
local.contributor.firstnameIliasen
local.subject.for2008070708 Veterinary Parasitologyen
local.subject.for2008070202 Animal Growth and Developmenten
local.subject.for2008070103 Agricultural Production Systems Simulationen
local.subject.seo2008970107 Expanding Knowledge in the Agricultural and Veterinary Sciencesen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailylaurens@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170316-163028en
local.publisher.placeUnited Kingdomen
local.format.startpage258en
local.format.endpage271en
local.identifier.scopusid84999854380en
local.peerreviewedYesen
local.identifier.volume6en
local.identifier.issue3en
local.access.fulltextYesen
local.contributor.lastnameBerken
local.contributor.lastnameLaurensonen
local.contributor.lastnameForbesen
local.contributor.lastnameKyriazakisen
dc.identifier.staffune-id:ylaurensen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20575en
dc.identifier.academiclevelAcademicen
local.title.maintitleModelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calvesen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorBerk, Zoeen
local.search.authorLaurenson, Yanen
local.search.authorForbes, Andrew Ben
local.search.authorKyriazakis, Iliasen
local.uneassociationUnknownen
local.identifier.wosid000393046300014en
local.year.published2016en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/b420f44e-fc74-4a0b-ac37-19ac6fbfa8f9en
local.subject.for2020300909 Veterinary parasitologyen
local.subject.for2020300301 Animal growth and developmenten
local.subject.for2020300205 Agricultural production systems simulationen
local.subject.seo2020280101 Expanding knowledge in the agricultural, food and veterinary sciencesen
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