Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20346
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dc.contributor.authorDever, M Len
dc.contributor.authorKahn, Lewisen
dc.contributor.authorDoyle, Emmaen
dc.contributor.authorWalkden-Brown, Steve Wen
dc.date.accessioned2017-04-06T16:36:00Z-
dc.date.issued2016-
dc.identifier.citationVeterinary Parasitology, v.216, p. 23-32en
dc.identifier.issn1873-2550en
dc.identifier.issn0304-4017en
dc.identifier.urihttps://hdl.handle.net/1959.11/20346-
dc.description.abstractThe hypothesis tested in this experiment was that 'Trichostrongylus colubriformis' infection would reduce growth rates of grazing meat-breed lambs; however production loss would be reduced by suppression of the host immune response. The experiment had a 3 × 2 factorial design using 6-7 month old meatbreed lambs which remained uninfected or infected (IFY) with 2000 or 4000 'T. colubriformis' L3/week for 12 weeks and were immunosuppressed (SUPY) using methylprednisolone acetate once weekly or remained non-immunosuppressed (SUPN). Immunosuppression increased worm egg counts (WEC) of infected lambs (SUPY 2421 eggs per gram (epg), SUPN 1154 epg on day 84, p < 0.05) and 'T. colubriformis' burdens (p < 0.05-0.10) and reduced circulating eosinophils (p < 0.05 on days 11, 42, 56 and 84) and intestinal total antibody titres (p < 0.02). There was a significant (p < 0.05) interaction between the main effects of infection and immunosuppression with infection having a larger negative effect on the liveweight of nonimmunosuppressed lambs. The immunological response of the host to 'T. colubriformis' infection accounted for 75% of the overall cost of infection (3.1 kg) with the majority of this cost occurring during the first 35 days of infection. In contrast, most of the cost associated with the direct effect of infection occurred after day 35. These results confirm in grazing meat-breed lambs that the host's immunological response to 'T. colubriformis' infection is the major component of production loss.en
dc.languageenen
dc.publisherElsevier BVen
dc.relation.ispartofVeterinary Parasitologyen
dc.titleImmune-mediated responses account for the majority of production loss for grazing meat-breed lambs during 'Trichostrongylus colubriformis' infectionen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.vetpar.2015.11.017en
dc.subject.keywordsVeterinary Parasitologyen
dc.subject.keywordsAnimal Protection (Pests and Pathogens)en
local.contributor.firstnameM Len
local.contributor.firstnameLewisen
local.contributor.firstnameEmmaen
local.contributor.firstnameSteve Wen
local.subject.for2008070708 Veterinary Parasitologyen
local.subject.for2008070205 Animal Protection (Pests and Pathogens)en
local.subject.seo2008830310 Sheep - Meaten
local.subject.seo2008830311 Sheep - Woolen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emaillkahn3@une.edu.auen
local.profile.emailedoyle3@une.edu.auen
local.profile.emailswalkden@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20170316-160932en
local.publisher.placeNetherlandsen
local.format.startpage23en
local.format.endpage32en
local.identifier.scopusid84955620723en
local.peerreviewedYesen
local.identifier.volume216en
local.contributor.lastnameDeveren
local.contributor.lastnameKahnen
local.contributor.lastnameDoyleen
local.contributor.lastnameWalkden-Brownen
dc.identifier.staffune-id:lkahn3en
dc.identifier.staffune-id:edoyle3en
dc.identifier.staffune-id:swalkdenen
local.profile.orcid0000-0002-3679-4530en
local.profile.orcid0000-0002-5255-2187en
local.profile.orcid0000-0002-0638-5533en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20543en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleImmune-mediated responses account for the majority of production loss for grazing meat-breed lambs during 'Trichostrongylus colubriformis' infectionen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorDever, M Len
local.search.authorKahn, Lewisen
local.search.authorDoyle, Emmaen
local.search.authorWalkden-Brown, Steve Wen
local.uneassociationUnknownen
local.identifier.wosid000369469800006en
local.year.published2016en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/46394f5c-ed91-481c-880e-db3b86681701en
local.subject.for2020300909 Veterinary parasitologyen
local.subject.for2020300304 Animal protection (incl. pests and pathogens)en
local.subject.seo2020100412 Sheep for meaten
local.subject.seo2020100413 Sheep for woolen
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School of Environmental and Rural Science
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