Phase-Contrast Clinical Breast CT: Optimization of Imaging Setups and Reconstruction Workflows

2016

Tromba, Giuliana

Pacile, Serena

Thompson, Darren

Brown, Jeremy M C

Lockie, Darren

Tonutti, Maura

Stacul, Fulvio

Zanconati, Fabrizio

Accardo, Agostino

Gureyev, Timur

Nesterets, Yakov

Brun, Francesco

Dullin, Christian

Dreossi, Diego

Mayo, Sheridan C

Stevenson, Andrew W

Pavlov, Konstantin M

Kitchen, Markus J

Journal Article

en

Publication

Springer

Germany

10.1007/978-3-319-41546-8_78

une:20303

We present the outcomes of combined feasibility studies carried out at Elettra and Australian Synchrotron to evaluate novel protocols for three-dimensional (3D) mammographic phase contrast imaging. A custom designed plastic phantom and some tissue samples have been studied at diverse resolution scales and experimental conditions. Several computed tomography (CT) reconstruction algorithms with different pre-processing and post-processing steps have been considered. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. The images were quantitatively evaluated using objective quality indices in comparison with subjective assessments performed by three experienced radiologists and one pathologist. We show that the propagation-based phase-contrast imaging (PBI) leads to substantial improvement to the contrast-to-noise and to the intrinsic quality of the reconstructed CT images compared with conventional techniques as well as to an important reduction of the delivered doses, thus opening the way to clinical implementations.

link

Lecture Notes in Computer Science, v.9699, p. 625-634

1611-3349

0302-9743

625

634