Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20057
Title: Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis
Contributor(s): Pearson, Melissa  (author)orcid ; Smart, Neil  (author)orcid 
Publication Date: 2017
DOI: 10.1016/j.ijcard.2016.12.145
Handle Link: https://hdl.handle.net/1959.11/20057
Abstract: Objective: Endothelial dysfunction contributes to the development and progression of cardiovascular disease and heart failure (HF) and is associated with an increased risk of mortality. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and is improved with exercise training in heart failure patients. The aim of this meta-analysis is to quantify the effect of exercise training in patients with heart failure. Background: A large number of studies now exist that have examined endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of exercise training on endothelial function. Methods: We conducted database searches (PubMed, EMBASE, PROQUEST and Cochrane Trials Register to June 2016) for exercise based rehabilitation trials in heart failure, using search terms exercise training, endothelial function, flow-mediated dilation (FMD) and endothelial progenitor cells (EPCs). Results: The 16 included studies provided a total of 529 participants, 293 in an intervention and 236 in controls groups. FMD was improved with exercise training in exercise vs. control, SMD of 1.08 (95%CI 0.70 to 1.46, p. <. 0.00001). Conclusion: Overall exercise training improved endothelial function, assessed via FMD, and endothelial progenitor cells in heart failure patients.
Publication Type: Journal Article
Source of Publication: International Journal of Cardiology, v.231, p. 234-243
Publisher: Elsevier Ireland Ltd
Place of Publication: Ireland
ISSN: 1874-1754
0167-5273
Fields of Research (FoR) 2008: 110201 Cardiology (incl. Cardiovascular Diseases)
110602 Exercise Physiology
Fields of Research (FoR) 2020: 320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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