Pearson, Melissa; Smart, Neil

Author(s)

Pearson, Melissa

Smart, Neil

Publication Date

2017

Abstract

Objective: Endothelial dysfunction contributes to the development and progression of cardiovascular disease and heart failure (HF) and is associated with an increased risk of mortality. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and is improved with exercise training in heart failure patients. The aim of this meta-analysis is to quantify the effect of exercise training in patients with heart failure. Background: A large number of studies now exist that have examined endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of exercise training on endothelial function. Methods: We conducted database searches (PubMed, EMBASE, PROQUEST and Cochrane Trials Register to June 2016) for exercise based rehabilitation trials in heart failure, using search terms exercise training, endothelial function, flow-mediated dilation (FMD) and endothelial progenitor cells (EPCs). Results: The 16 included studies provided a total of 529 participants, 293 in an intervention and 236 in controls groups. FMD was improved with exercise training in exercise vs. control, SMD of 1.08 (95%CI 0.70 to 1.46, p. <. 0.00001). Conclusion: Overall exercise training improved endothelial function, assessed via FMD, and endothelial progenitor cells in heart failure patients.

Citation

International Journal of Cardiology, v.231, p. 234-243

ISSN

1874-1754

0167-5273

Link

https://hdl.handle.net/1959.11/20057

Publisher

Elsevier Ireland Ltd

Title

Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis

Type of document

Journal Article

Entity Type

Publication

Author(s)	Pearson, Melissa Smart, Neil
Publication Date	2017
Abstract	Objective: Endothelial dysfunction contributes to the development and progression of cardiovascular disease and heart failure (HF) and is associated with an increased risk of mortality. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and is improved with exercise training in heart failure patients. The aim of this meta-analysis is to quantify the effect of exercise training in patients with heart failure. Background: A large number of studies now exist that have examined endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of exercise training on endothelial function. Methods: We conducted database searches (PubMed, EMBASE, PROQUEST and Cochrane Trials Register to June 2016) for exercise based rehabilitation trials in heart failure, using search terms exercise training, endothelial function, flow-mediated dilation (FMD) and endothelial progenitor cells (EPCs). Results: The 16 included studies provided a total of 529 participants, 293 in an intervention and 236 in controls groups. FMD was improved with exercise training in exercise vs. control, SMD of 1.08 (95%CI 0.70 to 1.46, p. <. 0.00001). Conclusion: Overall exercise training improved endothelial function, assessed via FMD, and endothelial progenitor cells in heart failure patients.
Citation	International Journal of Cardiology, v.231, p. 234-243
ISSN	1874-1754 0167-5273
Link	https://hdl.handle.net/1959.11/20057
Publisher	Elsevier Ireland Ltd
Title	Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis
Type of document	Journal Article
Entity Type	Publication

Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis

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