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Title: Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants
Contributor(s): Hu, Yingxue (author); Zou, Wenyue (author); Julita, Villy (author); Ramanathan, Rajesh (author); Tabor, Rico F (author); Nixon-Luke, Reece (author); Bryant, Gary (author); Bansal, Vipul (author); Wilkinson, Brendan  (author)orcid 
Publication Date: 2016
Open Access: Yes
DOI: 10.1039/c6sc03020cOpen Access Link
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Abstract: Naturally occurring and synthetic carbohydrate amphiphiles have emerged as a promising class of antimicrobial and antiadhesive agents that act through a number of dynamic and often poorly understood mechanisms. In this paper, we provide the first report on the application of azobenzene trans-cis photoisomerization for effecting spatial and temporal control over bacterial growth and biofilm formation using carbohydrate-based surfactants. Photocontrollable surface tension studies and small angle neutron scattering (SANS) revealed the diverse geometries and dimensions of self-assemblies (micelles) made possible through variation of the head group and UV-visible light irradiation. Using these light-addressable amphiphiles, we demonstrate optical control over the antibacterial activity and formation of biofilms against multi-drug resistant (MDR) 'Pseudomonas aeruginosa', methicillin-resistant 'Staphylococcus aureus' (MRSA) and Gram-negative 'Escherichia coli'. To probe the mechanism of bioactivity further, we evaluated the impact of trans-cis photoisomerization in these surfactants on bacterial motility and revealed photomodulated enhancement in swarming motility in 'P. aeruginosa'. These light-responsive amphiphiles should attract significant interest as a new class of antibacterial agents and as investigational tools for probing the complex mechanisms underpinning bacterial adhesion and biofilm formation.
Publication Type: Journal Article
Grant Details: ARC/DE130101673
Source of Publication: Chemical Science, 7(11), p. 6628-6634
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 2041-6539
Field of Research (FOR): 030503 Organic Chemical Synthesis
030399 Macromolecular and Materials Chemistry not elsewhere classified
030401 Biologically Active Molecules
Socio-Economic Outcome Codes: 929999 Health not elsewhere classified
970103 Expanding Knowledge in the Chemical Sciences
970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
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