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Title: Peripheral cellular and humoral responses to infestation with the cattle tick 'Rhipicephalus microplus' in Santa Gertrudis cattle
Contributor(s): Piper, E K (author); Jonsson, N N (author); Gondro, Cedric  (author)orcid ; Vance, M E (author); Lew-Tabor, A (author); Jackson, L A (author)
Publication Date: 2017
Open Access: Yes
DOI: 10.1111/pim.12402
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Abstract: Resistance to cattle tick infestation in single-host ticks is primarily manifested against the larval stage and results in the immature tick failing to attach successfully and obtain a meal. This study was conducted to identify immune responses that characterize the tick-resistant phenotype in cattle. Thirty-five tick-naїve Santa Gertrudis heifers were used in this study, thirty of which were artificially infested for thirteen weeks with tick larvae while five animals remained at a tick-free quarantine property to serve as a control group. Following thirteen weeks of tick infestation, the animals in this trial exhibited highly divergent tick-resistant phenotypes. Blood samples collected throughout the trial were used to measure peripheral immune parameters: haematology, the percentage of cellular subsets comprising the peripheral blood mononuclear cell (PBMC) population, tick-specific IgG₁ and IgG₂ antibody titres, IgG1 avidity for tick antigens and the ability of PBMC to recognize and proliferate in response to stimulation with tick antigens in vitro. The tick-susceptible cattle developed significantly higher tick-specific IgG₁ antibody titres compared to the tick-resistant animals. These results suggest that the heightened antibody response either does not play a role in resistance or might contribute to increased susceptibility to infestation.
Publication Type: Journal Article
Source of Publication: Parasite Immunology, 39(1), p. 1-12
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: United Kingdom
ISSN: 1365-3024
Fields of Research (FoR) 2008: 070202 Animal Growth and Development
070201 Animal Breeding
070203 Animal Management
Fields of Research (FoR) 2020: 300301 Animal growth and development
300305 Animal reproduction and breeding
300302 Animal management
Socio-Economic Objective (SEO) 2008: 830301 Beef Cattle
Socio-Economic Objective (SEO) 2020: 100401 Beef cattle
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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