Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/19791
Title: Exercise training in heart failure patients with preserved ejection fraction: a systematic review and meta-analysis
Contributor(s): Chan Erick, (author); Giallauria, Francesco  (author); Vigorito, Carlo (author); Smart, Neil  (author)orcid 
Publication Date: 2016
Open Access: Yes
DOI: 10.4081/monaldi.2016.759Open Access Link
Handle Link: https://hdl.handle.net/1959.11/19791
Abstract: Exercise training induces physical adaptations for heart failure patients with systolic dysfunction but less is known about those patients with preserved ejection fraction. This study's aims were to establish if exercise training produces changes in peak VO2 and related measures, quality of life, general health and diastolic function in heart failure patients with preserved ejection fraction (HFpEF). We conducted a MEDLINE search (1985 to September 1, 2015), for exercise based rehabilitation trials in heart failure, using search terms 'exercise training, heart failure with preserved ejection fraction, heart failure with normal ejection fraction, peak VO2 and diastolic heart dysfunction'. Eight intervention studies were included providing a total of 174 exercising subjects and 143 control subjects, a total of 317 participants. Peak VO2 increased by a mean difference (MD) 2.08 mL kg-1 min-1 (95% C.I. 1.51 to 2.65, p<0.00001) in exercise training versus sedentary control, equating to a 17% improvement from baseline. VE/VCO2 slope was not different between groups, MD -3.10 mL kg-1 min-1 (95% C.I. -7.47 to 1.27, p=0.16); maximum heart rate was significantly increased in exercise groups, MD 3.46 bpm (95% C.I. 2.41 to 4.51, p<0.00001); 6 Minute Walk Distance (6MWT) MD 32.1m (95% C.I. 17.2 to 47.1, p<0.0001); diastolic function; the ratio of early to late filling (E/A ratio) was improved after exercise training MD 0.07 (95% C.I. 0.02 to 0.12, p=0.006); as was filling pressure E/E' ratio MD -2.38 (95% C.I. -3.47 to -1.28, p<0.0001); Deceleration time (DT) MD -13.2 msec (95% C.I. -19.8 to -6.5, p=0.0001); Minnesota Living with Heart Failure Questionnaire (MLHFQ) MD -6.77 (95% C.I. -9.70 to -3.84, p<0.00001); Short Form-36 Health Survey MD 11.38 (95% C.I. 5.28 to 17.48, p=0.0003). In 3222 patient-hours of training, not a single death was directly attributable to exercise. Exercise training appears to effect several health-related improvements in people with heart failure and preserved ejection fraction.
Publication Type: Journal Article
Source of Publication: Monaldi Archives for Chest Disease: Cardiac Series, 86(1-2), p. 1-9
Publisher: Pagepress
Place of Publication: Italy
ISSN: 2465-1028
1122-0643
Fields of Research (FoR) 2008: 110201 Cardiology (incl. Cardiovascular Diseases)
Fields of Research (FoR) 2020: 320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

Files in This Item:
3 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

51
checked on Aug 17, 2024

Page view(s)

1,566
checked on May 19, 2024
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.