The Iridoid Myodesert-1-ene and Elemol/Eudesmol are found in Distinct Chemotypes of the Australian Aboriginal Medicinal Plant 'Eremophila dalyana' (Scrophulariaceae)

Title
The Iridoid Myodesert-1-ene and Elemol/Eudesmol are found in Distinct Chemotypes of the Australian Aboriginal Medicinal Plant 'Eremophila dalyana' (Scrophulariaceae)
Publication Date
2016
Author(s)
Sadgrove, Nicholas
Collins, Timothy
Legendre, Sarah
Klepp, Julian
Jones, Graham L
( author )
OrcID: https://orcid.org/0000-0002-6435-1542
Email: gjones2@une.edu.au
UNE Id une-id:gjones2
Greatrex, Ben
( author )
OrcID: https://orcid.org/0000-0002-0356-4966
Email: bgreatre@une.edu.au
UNE Id une-id:bgreatre
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Natural Product Inc
Place of publication
United States of America
UNE publication id
une:19764
Abstract
The strongly aromatic Australian desert species 'Eremophila dalyana' is an Aboriginal medicinal plant that continues to be used today in Central Australia in the treatment of respiratory complaints and 'Sarcoptes scabiei' infestation. Using hydrodistillation of aerial parts of the plant, the new natural product myodesert-1- ene was isolated in two disjunct populations at up to 98% of the volatiles present in the hydrodistilled oils. Weak antimicrobial activities were observed for whole oils and myodesert-1-ene. Activities in the hydrodistilled oil were attributed to the antimicrobial sesquiterpenes elemol and eudesmol which showed good activity when isolated and were relatively abundant in the chemotype used medicinally. The biogenesis of myodesert-1-ene from iridodial is proposed.
Link
Citation
Natural Product Communications, 11(9), p. 1211-1214
ISSN
1555-9475
1934-578X
Start page
1211
End page
1214

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